Background: Clomiphene Citrate (CC) is the most frequently administered drug for the treatment of female infertility [e.g. polycystic ovary syndrome (PCOS)]; which aims at restoring ovulation. Clomiphene is metabolized by CYP2D6, an important enzyme responsible for the metabolism of approximately 25% of clinically used drugs. CYP2D6 is very polymorphic and thought to result in inter- individual...

Aim Polycystic ovary syndrome (PCOS) is an ovulatory disorder and insulin resistance and diabetes are involved in its pathophysiology. Metformin, an anti-diabetic agent, has been reported to be useful to induce ovulation. Methods Metformin treatment was classified into four types: (1) clomiphene-metformin combination treatment for clomiphene-resistant patients; (2) clomiphene-metformin combin...

BACKGROUND The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior. METHODS We randomly assigned 626 infertile women with the polycystic ovary syndrome to receive clomiphene citrate plus placebo, extended-release metformin plus placebo, or a comb...

background: poor ovarian response to controlled ovarian stimulation is one of the most important interest points in assisted reproduction. mild ovarian stimulation seems to be preferable to high dose of fsh regimens in women with a history of poor ovarian response in previous protocol. clomiphene citrate and letrozole alone or in combination with fsh have been used in mild ovarian stimulation p...

121 women with polycystic ovarian syndrome and clomiphene citrate resistance underwent laparoscopic ovarian cautery, 63 patients were type i or typical pcos with ovarian volume >8ml and 58 patients were type ii pcos with ovarian volume <8ml. serum concentrations of luteinizing hormone (lh), follicular stimulating hormone (fsh), prolactin (prl), testosterone (t), and dehydroepiandrosterone sulfa...

objective: the study aimed to evaluate the effectiveness of laparoscopic ovarian drilling (lod) on ovulation and restoration of menstrual cycles andpregnancy.  materials and m ethods : this cross sectional study was conducted on 81 consecutive polycystic ovarian syndrome (pco) patients whom were referred to  avesina infertility clinic during 2003-2006. exclusion criteria were tubal and male fac...

We present a case of a 29 year old nulliparous woman with clomiphene resistance polycystic ovarian syndrome. She had a successful laparoscopic ovarian drilling (LOD) in a private fertility centre in Nnewi Southeast Nigeria. She achieved a pregnancy four months later following clomiphene citrate ovulation induction. The pregnancy was complicated with 1st trimester threatened abortion, pre-term P...