Peptides from the lumenal portion of invariant chain (Ii) spanning residues 80-106 (class II-associated Ii peptide [CLIP]) are found in association with several mouse and human major histocompatibility complex (MHC) class II allelic variants in wild-type and presentation-deficient mutant cells. The ready detection of these complexes suggests that such an intermediate is essential to the MHC cla...

Duodenal endoscopic mucosal resection (EMR) carries a high risk of adverse events, including delayed perforation [1, 2]. Because complete clip closure of mucosal defects can reportedly prevent post-procedural adverse events in the colorectum, we established a line-assisted complete closure (LACC) technique for large mucosal defects after colonic endoscopic submucosal dissection [3]. LACC can be...

Selective synthesis of 4-(sulfonyl)-methyl-1H-pyrazoles and (E)-4,5-dihydro-1H-pyrazoles from N-allenic sulfonylhydrazones with sulfonyl group migrations has been developed. A key feature of these reactions is that the migrations of the sulfonyl groups to different positions can be controlled by changing the Lewis acids.

The use of CT angiography is described in three patients for the evaluation of intracranial clips after surgery for an aneurysm. A postprocessing technique is described in which shaded-surface-display models were superimposed on maximum intensity projection CT angiograms. CT angiograms showed residual aneurysmal filling adjacent to a clip, patency of a vessel thought to be compromised by recent...

Whereas many molecules that promote cell and axonal growth cone migrations have been identified, few are known to inhibit these processes. In genetic screens designed to identify molecules that negatively regulate such migrations, we identified CRML-1, the C. elegans homolog of CARMIL. Although mammalian CARMIL acts to promote the migration of glioblastoma cells, we found that CRML-1 acts as a ...

This paper aims to show the benefits of choosing Linux and migrating existing UNIX environments to the Linux platform. This applies in particular to migrations from RISC-based platforms. It also shows the extent to which Linux is now a trusted, mainstream platform and how any technical risks associated with migrations can be mitigated. This paper addresses a technical audience.

be a distinct class of accessory factors, which we term " plus-end-tracking proteins " or ϩTIPs. These MAPs are among the most conserved components of the MT cy-toskeleton. They localize to the MT plus end, and in living cells, they mark growing plus ends and thus give The Children's Hospital the appearance of " tracking. " Recently, studies from a Harvard Medical School variety of organisms ha...

PURPOSE The threshold estimation, learning effect, and between-algorithm differences of the Fast Swedish Interactive Thresholding Algorithm (SITA Fast), of the Humphrey Field Analyzer (HFA), and the Continuous Light Increment Perimetry (CLIP) strategy of the Oculus Twinfield perimeter were evaluated in damaged visual fields. METHODS Twenty-one glaucomatous patients with damaged visual fields ...

Cross-linking immunoprecipitation coupled with high-throughput sequencing (CLIP-Seq) has made it possible to identify the targeting sites of RNA-binding proteins in various cell culture systems and tissue types on a genome-wide scale. Here we present a novel model-based approach (MiClip) to identify high-confidence protein-RNA binding sites from CLIP-seq datasets. This approach assigns a probab...

The presentation of antigenic peptides by major histocompatibility complex (MHC) class II to CD4+ T cells is crucial to initiate immune responses. We developed a new system for delivery of an antigenic peptide to the MHC class II pathway, using the invariant chain (Ii). We designed a mutated human p33-form Ii, CLIP-substituted Ii, in which streptococcal M12p55-68 (RDLEQAYNELSGEA) was substitute...