Abstract Background DNA methylation is involved in pathogenesis of acute myeloid leukemia (AML). N6-methyladenosine (m6A) modification mRNA, mediated by methyltransferase-like 3 ( METTL3 ), one the well-identified mRNA modifiers associated with AML. High level detected AML cells, thus can be a potential target therapy for This preliminary study that aimed at measuring expression de novo patient...

PURPOSE The members of the Smad family play key rolesin regulating gene expression in the transforming growth factor (TGF)-beta1 signaling pathways. Activation of Smads causes their translocation from the cytoplasm to the nucleus, where they function as transcription factors. The present study analyzed the expression and clinicopathological significance of Smad4 and TGF-beta1 in squamous cell c...

PURPOSE Signet ring cell carcinoma (SRCC) is rare. The aim of this study is to understand the clinicopathological features and identify the possible prognostic factors in colorectal SRCC. METHODS Patients with SRCC who underwent primary lesion resection at Fudan University Shanghai Cancer Center from September 2008 to July 2014 were retrospectively analyzed. Patient's gender, age, tumor locat...

Little is known about clinicopathological characteristics of gastric carcinoma (GC) in young (≤40 years) Chinese patients. We aimed in this study to analyze those features along with family history and prognostic factors after resection. We retrospectively reviewed all 4671 GC resections (surgical and endoscopic) performed at our center from 2004 to 2014 and identified 152 (3.2%) consecutive yo...

The incidence of young cases of breast cancer is higher in China compared to the western world. We aimed to explore differences in risk factors, clinicopathological features and treatment modes of young female breast cancer compared to older patients in West China. We collected clinical information from 12,209 female breast cancer patients in West China, including risk factors, clinicopathologi...

The colorectal cancer (CRC) patients with microsatellite instability (MSI) have distinct clinicopathological characteristics consisting of factors predicting positive and negative outcomes, such as a high lymph node harvest and poor differentiation. In this study, we measured the value of MSI as a prognostic factor after controlling for these discrepant factors. A total of 603 patients who unde...

PURPOSE Histone deacetylase 6 (HDAC6) is an enzyme that deacetylates heat-shock protein 90 (HSP90). Many studies have investigated the role of HDAC6 and HSP90 in tumorigenesis and in the prognosis of cancer patients. This study aimed to evaluate the prognostic value of HDAC6 and acetylated HSP90 (acetyl-HSP90) in a cohort of breast cancer patients. METHODS Immunohistochemical analysis of 314 ...

Signal transducers and activators of transcription (STATs) belong to a family of transcription factors activated in response to cytokines and growth factors. Constitutive activation of STAT3 has been observed in a growing number of tumour-derived cell lines, as well as in tumor specimens from human cancers. Our aim was to determine the relationship between the expression of phosphorylated STAT3...

Coronary Artery Disease is an insidious disease which can present clinically with sudden onset of Symptoms that necessitate hospitalization and life saving intervention. The spectrum clinicopathological entities range from Stable Angina, Untable Angina Acute Syndrome. last but not the least entity threatening condition significant Morbidity Mortality unless timely treatment given. There are man...

to evaluate the prognostic significance of clinicopathological measurement in the diagnosis of acute myocardial infarction (mi) in sheep, acute mi was induced by ligation of left anterior descending coronary artery (lad). for this purpose, twenty four healthy sheep were divided into the sham-operated or control group (group i, thoracotomy without mi) and the experimental group (group ii, with m...