نتایج جستجو برای: clinical trial committee
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In the analysis of dependence of bivariate correlated failure time data, a popular model is a gamma frailty model proposed by Clayton and Oakes. An alternative approach is using a Plackett distribution, whose dependence parameter has a very appealing odds ratio interpretation for dependence between the two failure times. In this article, we develop novel semiparametric estimation and inference ...
We show that under reasonable conditions the nonparametric maximum likelihood estimate (NPMLE) of the distribution function from left-truncated and case 1 interval-censored data is inconsistent, in contrast to the consistency properties of the NPMLE from only left-truncated data or only interval-censored data. However, the conditional NPMLE is shown to be consistent. Numerical examples are prov...
.....in which Professor Benchie, an established super-subspeciality clinician who spends most of his time performing laboratory research, profers advice toAthena, an enthusiastic early career physician who, although she spent summers in the lab as a medical student, is just finishing a research fellowship that included a course in clinical research and wonders whether she would prefer to devote...
OCTOBER 2002 Abstract Objectives: To review the evidence-based management of nausea and vomiting of pregnancy (NVP) and hyperemesis gravidarum. Evidence: MEDLINE and Cochrane database searches were performed using the medical subject headings (MeSH) of treatment, nausea, vomiting, pregnancy, and hyperemesis gravidarum. The quality of evidence reported in these guidelines has been described usin...
Longitudinal data occur in many fields such as the medical follow-up studies that involve repeated measurements. For their analysis, most existing approaches assume that the observation or follow-up times are independent of the response process either completely or given some covariates. In practice, it is apparent that this may not be true. In this paper, we present a joint analysis approach t...
We provide a review on the empirical likelihood method for regression type inference problems. The regression models considered in this review include parametric, semiparametric and nonparametric models. Both missing data and censored data are accommodated.
Many studies have demonstrated that the children of divorce are disproportionately likely to end their own marriages. In previous work, I showed that the transmission of divorce between generations weakened substantially for General Social Survey (GSS) respondents interviewed between 1973 and 1996 (Wolfinger 1999); Li and Wu (2006, 2008) contended that my finding is a methodological artifact of...
Motivated by a longitudinal oral health study, we propose a flexible modeling approach for clustered time-to-event data, when the response of interest can only be determined to lie in an interval obtained from a sequence of examination times (interval-censored data) and on top of that, the determination of the occurrence of the event is subject to misclassification. The clustered time-to-event ...
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