AIMS To compare plasma myoglobin concentration and cardiac enzyme activity with electrocardiographic (ECG) changes in two groups of patients (reperfused and non-reperfused) participating in a placebo-controlled randomised double blind trial of treatment of myocardial infarction (MI) with intravenous thrombolytic therapy (Anistreplase). METHODS Twenty two patients with confirmed MI obeying str...

OBJECTIVE Oxidative stress as a result of reperfusion injury is a known causative factor of cardiac muscle injury. In the peripheral blood as well in the coronary sinus, oxidative stress parameters and cardiac biomarkers were measured to investigate the different levels of oxidative stress during three different CABG techniques; MCABG (with minimal prime volume and warm blood cardioplegia) that...

OBJECTIVE To determine high sensitivity C-reactive protein (hsCRP) levels in patients with acute myocardial infarction (AMI) and its correlation with classical enzyme markers of myocardial damage. STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY Department of Emergency Medicine at King Khalid University Hospital, King Saud University, Riyadh and Department of Physiology, from A...

This study compared efficacy of two polyvalent antivenoms (Saudi Arabian and Egyptian), against lethality and pathophysiological changes of Leiurus quinquestriatus quinquestriatus (LQQ) scorpion venom in mice. Additionally, the study examined whether treatment with selected ion channel modulators, lidocaine, nimodipine or amiodarone would be effective, alone or combined with the antivenoms. The...

BACKGROUND: Cardiovascular system is a very importantorgan that plays a vital role in tissue function. In farm animals,the growth and high milk production depends on function ofcardiovascular system. OBJECTIVES: Cardiovascular health inhigh and low-yielding dairy cows was investigated. METHODS:Fifty 4-year-old high- yielding Holstein dairy cows and fifty 4-year-old low- yielding Holstein dairy ...

IL-37 is a newly discovered natural inflammatory inhibitor in recent years. The role and mechanism of IL37 in the inflammatory reaction of atherosclerosis in patients with coronary artery disease may be related to the abnormal blood lipid and regulatory T cells (Tregs). But the effect of IL-37 on myocardial ischemia reperfusion injury and its mechanism are still not clear. Therefore, this study...

BACKGROUND Beyond lipid lowering, statins are known to possess antiinflammatory and antithrombotic properties. Recent studies suggested an association between statins and early reduction in death or myocardial infarction (MI) after percutaneous coronary interventions (PCIs). We sought to examine the interrelationship between inflammation, statin use, and PCI outcomes. METHODS AND RESULTS In t...

to produce reliable results. This conclusion is based on the study by Obzansky and Lott (2), which involved the Cardiozyme (Dade Div., American Hospital Supply Corp., Miami, FL 33152) immunoinhibition test for CKMB. Two other assays based on similar principles-EskachemTM CK-MB Reagent (SmithKbine Instruments, Inc., Sunnyvale, CA 94086) and A-gent CK-MB (Abbott Labs., North Chicago, IL 60064)-ar...

BACKGROUND AND OBJECTIVE Evidence is growing regarding the prognostic value of markers of inflammation in unstable angina/non-ST segment elevation myocardial infarction (UA/NSTEMI). However, the independent value of these variables has not been systematically investigated in prospective studies. The main objective of the SIESTA study is to assess the relative prognostic roles of C-reactive prot...

OBJECTIVE To evaluate the impact of preoperative oral trimetazidine on myocardial protection in coronary bypass surgery. METHODS We conducted a prospective double blind randomized study in the Department of Cardiac Surgery, Chaudhry Pervaiz Elahi (CPE) Institute of Cardiology, Multan, Pakistan. One hundred and seventy (170) patients of isolated CABG were included in the study. All operations ...