premature ejaculation (pe) is one of prevalent male sexual dysfunctions worldwide. despite many psychiatric backgrounds, yet there are speculations about organic etiologies considering both anatomic and physiologic points of view. this survey assesses effect of frenular web preservation on premature ejaculation. one thousand and forty otherwise healthy men being visited for urolithiasis (asympt...

BACKGROUND No drugs are approved for treatment of premature ejaculation. Our aim was to determine the efficacy and tolerability of on-demand dapoxetine in patients with severe premature ejaculation. METHODS We determined the efficacy of dapoxetine in a prospectively predefined integrated analysis of two 12-week randomised, double-blind, placebo-controlled, phase III trials of identical design...

OBJECTIVE The aim of this study is to create a rank order of the comparative efficacy and acceptability (risk of all-cause discontinuation) of antidepressant treatment in poststroke depression (PSD) by integrating direct and indirect evidence. DESIGN Multiple-treatments meta-analysis of randomised controlled trials. PARTICIPANTS Patients with depression following stroke. INTERVENTIONS 10 ...

The precise neurochemical effects of antidepressants that underlie their efficacy remain unclear. Many antidepressants modulate noradrenaline transmission in vivo. However, the selective serotonin reuptake inhibitors (SSRIs) and NK1 receptor antagonists target 5-HT and substance P transmission, respectively. Whether effects on noradrenaline neurones contribute to the efficacy of these drugs has...

The second Ad Hoc International Society for Sexual Medicine (ISSM) Committee for the Definition of Premature Ejaculation defined acquired premature ejaculation (PE) as a male sexual dysfunction characterized by a the development of a clinically significant and bothersome reduction in ejaculation latency time in men with previous normal ejaculatory experiences, often to about 3 minutes or less, ...

BACKGROUND Premature ejaculation (PE) is the most prevalent male sexual dysfunction. Epidemiologic findings are inconsistent concerning the risk for depression associated with PE. OBJECTIVE The aim of this study was to investigate the potential association between between depression and risk of PE. DATA SOURCES We conducted a literature search of PubMed, Embase, and the Cochrane Library fro...

For many decades it has been thought that lifelong premature ejaculation (PE) is only characterized by persistent early ejaculations. Despite enormous progress of in vivo animal research, and neurobiological, genetic and pharmacological research in men with lifelong PE, our current understanding of the mechanisms behind early ejaculations is far from complete. The new classification of PE into ...

To analyze the experiences of laparoscopic radical cystectomy, modified Wallace ileal conduit retrospectively. To demonstrate the patient positioning, Trocar positioning, operational procedures, key steps and personal experiences of this approach, focusing on the operative techniques and post-operational outcomes of modified Wallace ileal conduit.

The management recommendation for both acquired premature ejaculation (APE) and lifelong PE (LPE) are similar, such as a behavioral/psychotherapy, a pharmacotherapy and a combination of these treatments. For the drug treatment for PE, gold standard is selective serotonin reuptake inhibitors (SSRIs) including dapoxetine or paroxetine. The drug treatment for PE is still developing and some new pr...

UNLABELLED Escitalopram (Cipralex), a new highly selective serotonin reuptake inhibitor (SSRI), is the active S-enantiomer of RS-citalopram. It is effective in the treatment of patients with major depressive disorder (MDD) and may have a faster onset of therapeutic effect than citalopram. It has also been shown to lead to improvements in measures of QOL. Escitalopram is generally well tolerated...