In the title complex, cis-[PtCl(4)(C(3)H(4)N(2))(2)], the Pt(IV) ion lies on a twofold rotation axis and is coordinated in a slightly distorted octa-hedral geometry. The dihedral angle between the imidazole rings is 69.9 (2)°. In the crystal, mol-ecules are linked by N-H⋯Cl hydrogen bonds, forming a three-dimensional network.

The success of the clinical uses of cisplatin, cis-[Pt(II)(NH(3))(2)Cl(2)], has stimulated considerable interest in using other metal complexes as new therapeutic agents. This perspective describes our recent work on several classes of gold(III), platinum(II), ruthenium(II, III, IV), iron(II) and vanadium(IV) complexes for anti-cancer and anti-HIV treatments.

In the title complex, [PtCl2(C6H16N2)], the Pt(II) atom adopts a distorted cis-PtN2Cl2 square-planar coordination geometry. The five-membered chelate ring adopts a twisted conformation. In the crystal, weak C-H⋯Cl hydrogen bonds link the mol-ecules into (001) sheets.

Of all properties of metal nucleobase complexes, formation of multinuclear species appears to be an outstanding feature. After a brief introduction into well known polymeric metal nucleobase complexes, three aspects recently Studied in our laboratory will be dealt with in more detail: (i) Heteronuclear complexes derived from trans-[(amine)(2)Pt(1-MeC)(2)](2+) (1-MeC=1-methylcytosine). They form...

The title compound, [PtCl(2)(C(9)H(21)O(3)P)(2)], was obtained from a solution of PtCl(2)(COD) (COD = 1,5-cyclooctadiene) and triisopropyl-phosphite in dichloro-methane. The complex features a Pt(II) atom coordinated by two Cl and two P atoms, yielding a slightly distorted cis square-planar geometry.

cis-[(Cy3P)2Pt{B(OMe)2}2] (1) was obtained in quantitative yield and fully characterised. The thermal stability of 1 was investigated in solution using multinuclear NMR spectroscopy revealing a hitherto unknown temperature-dependent equilibrium between 1 and the corresponding starting materials [Pt(PCy3)2] and free B2(OMe)4.

Two self-assembled redox-active cages are presented. They are obtained by coordination-driven self-assembly of a tetra-pyridile tetrathiafulvalene ligand with cis-M(dppf)(OTf)₂ (M = Pd or Pt; dppf = 1,1'-bis(diphenylphosphino)ferrocene; OTf = trifluoromethane-sulfonate) complexes. Both species are fully characterized and are constituted of 12 electro-active subunits that can be reversibly oxidi...

A new experiment using laser ablation with inductively coupled plasma mass spectrometry (LA-ICP-MS) was designed for chemistry undergraduate students. While most analytical methods only provide information on the amount of analyte, LA-ICP-MS allows extra distribution element in sample. Because it achieves excellent limits detection (sub μg·g–1) and high spatial resolution (micrometer scale), is...

The crystal structure of molybdenum triplatinum tetrasilicide, MoPt(3)Si(4), determined previously from powder diffraction data [Joubert et al. (2010 ▶). J. Solid State Chem.183, 173-179], has been redetermined using a single crystal synthesized from the elements by high-frequency melting. The redetermination provides more precise geometrical data and also anisotropic displacement parameters. T...

Binding to plasma proteins is one of the major metabolic pathways of metallodrugs. In the case of platinum-based anticancer drugs, it is the interaction with serum albumin that affects most strongly their in vivo behavior. Since both the configuration, i.e. cis-trans-isomerism, and the nature of leaving groups have an effect on the reactivity of Pt(II) coordination compounds toward biomolecules...