نتایج جستجو برای: ciliary neurotrophic factor cntfr

تعداد نتایج: 853570  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
François Rousseau Jean-François Gauchat James G McLeod Sylvie Chevalier Catherine Guillet Florence Guilhot Isabelle Cognet Josy Froger Angelika F Hahn Per M Knappskog Hugues Gascan Helge Boman

Ciliary neurotrophic factor (CNTF) receptor controls a pathway supporting the differentiation and survival of a wide range of neural cell types during development and in adulthood. Cardiotrophin-like cytokine (CLC)-cytokine-like factor 1 (CLF) composite cytokine is a second ligand for the CNTF alpha-component receptor (CNTFRalpha). This composite cytokine is built on the structural model of IL-...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1994
Q W Yin J Johnson D Prevette R W Oppenheim

In the absence of descending spinal and supraspinal afferent inputs, neurons in the developing lumbar spinal cord of the chick embryo undergo regressive changes including cellular atrophy and degeneration between embryonic days 10 and 16. There are significant decreases in the number of motoneurons, interneurons, and sensory (dorsal root ganglion) neurons. Although there are several possible ex...

Journal: :Neuron 1996
Ronald M Lindsay George D Yancopoulos

complement of dopaminergic neurons, and only minor GDNF: A Treatment for Parkinson’s Disease? losses of spinal motor neurons. Thus, the postulated Not long after success with ciliary neurotrophic factor role of GDNF as a developmentally important target(CNTF; Lin et al., 1989), Leu-Fen Lin and Frank Collins derived neurotrophic factor for nigral dopaminergic neurepeated the arduous task of char...

2016
Jakob Vejby Larsen Anders Mejer Kristensen Lone Tjener Pallesen Johannes Bauer Christian Bjerggaard Vægter Morten Schallburg Nielsen Peder Madsen Claus Munck Petersen

Cardiotrophin-like cytokine:cytokine-like factor-1 (CLC:CLF-1) is a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development. Mice lacking CLC:CLF-1 die soon after birth due to a suckling defect and show reduced numbers of motor neurons. Humans carrying mutations in CLC:CLF-1 develop similar disorders, known as Sohar-Crisponi or cold-induced sweating syndrome, an...

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