Hypertrophic scars and keloids are a problem that mainly dermatologists and plastic surgeons encounter. Especially in the head and neck region, these lesions are conspicuous and not easy for patients to conceal. Patients typically present with cosmetic concerns, although hypertrophic scars and keloids can also cause pruritus, pain, or pressure. This article reviews various treatment modalities ...

INTRODUCTION: Many studies have proved the role, efficacy and safety profile of intralesional bleomycin in the management of hypertrophic scars and keloids.1 Liposomes, by virtue of their lipid bilayer, have potential to enhance the delivery of drug to the desired area. Drugs encapsulated in liposomes are expected to be transported without rapid degradation and minimum side effects to the recip...

PURPOSE Our study aims to investigate the effectiveness of other treatment methods for burn related scarring and to determine the possibility of their routine administration in similar clinical settings. METHODS Through a prospective study, 66 patients were enrolled to receive either the conventional pressure garment therapy (PGT) and Silicone (control group) or exercise and physiotherapy (ca...

Severe burn injuries present a significant public health risk and are often associated with a life-threatening systemic inflammatory response. With the traditional approach, patients often stay in hospital longer and are more prone to problems like joint contractures, hypertrophic scars and infections due to delayed healing. The approach to burn injuries has been improving through and has been ...

BACKGROUND Cryotherapy combined with intralesional triamcinolon injection is the most common traditional therapy for hypertrophic scars and keloids. The literature contains few articles on the use of bleomycin tattoo for treatment of these conditions. OBJECTIVE This study compares the efficacy of bleomycin tattoo with that of cryotherapy combined with intralesional triamcinolon injection for ...

CONCLUSIONS: For the first time, our results reveal a decrease of the stemness marker CD34 in murine skin cells in hypertrophic scars over time compared to unwounded skin. We are currently conducting single cell transcriptional analyses and functional studies on these fibroblasts to understand the heterogeneity of fibroblasts during hypertrophic scarring and the specific role of CD34+ fibroblas...

Although itching (or pruritus) in a scar is a very common and distressing symptom and is increasingly being recognized as a significant obstacle in burn rehabilitation, the exact mechanisms underlying this symptom have not been elucidated; hence, a reliable therapy has not been established. Recent findings have suggested that itching caused by inflammatory dermatosis can be reduced by antihista...

BACKGROUND Open thyroidectomy is conventionally performed at the anterior side of neck, which is a body part with a comparatively great degree of open exposure; due to this, postoperative scarring may cause distress in patients. We aimed to compare the effects of ablative and nonablative fractional laser treatments on thyroidectomy scars. We examined medical records in a retrospective manner an...

Many techniques for management of hypertrophic scars and keloids have been proven through extensive use, but few have been supported by prospective studies with adequate control groups. Several new therapies showed good results in small-scale trials, but these have not been repeated in larger trials with long-term follow-up. This article reports a qualitative overview of the available clinical ...

BACKGROUND Keloid scars are common cutaneous lesions encountered by plastic surgeons. They are distinguished from normal scars and hypertrophic scars by their ability to spread outside the boundaries of the original scar. Corticosteroids are a mainstay of treatment, and their effectiveness is thought to be due to the inhibition of fibroblast growth and the promotion of collagen degradation. The...