The hypothalamic paraventricular nucleus (PVN) is the primary driver of hypothalamo-pituitary-adrenocortical (HPA) responses. At least part of the role of the PVN is managing the demands of chronic stress exposure. With repeated exposure to stress, hypophysiotrophic corticotropin-releasing hormone (CRH) neurons of the PVN display a remarkable cellular, synaptic, and connectional plasticity that...

Women are more susceptible to numerous stress-linked psychological disorders (e.g., depression) characterized by dysfunction of corticolimbic brain regions critical for emotion regulation and cognitive function. Although sparsely investigated, a number of studies indicate sex differences in stress effects on neuronal structure, function, and behaviors associated with these regions. We recently ...

OBJECTIVES Mental and physical stress can suppress the immune system in both humans and animals. The mechanism by which stress affects immune responses, however, remains poorly defined. Toll-like receptors (TLRs) play a key role in modulating immune responses and cell survival. The mechanisms by which TLRs modulate chronic stress are largely unexplored. METHODS Six- to 8-week-old male mice we...

UNLABELLED Social support has a positive influence on the course of a depression and social housing of rats could provide an animal model for studying the neurobiological mechanisms of social support. Male and female rats were subjected to chronic footshock stress for 3 weeks and pair-housing of rats was used to mimic social support. Rats were isolated or housed with a partner of the opposite s...

BACKGROUND Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and monocyte chemotactic protein-1 (MCP-1) have previously been suggested to be potential biomarkers for chronic stress induced exhaustion. The knowledge about VEGF has increased during the last decades and supports the contention that VEGF plays an important role in stress and depression. There is scarce knowle...

The mechanisms of response and adaptation the body's regulatory systems to stress factors is an urgent fundamental task goal this study. study used four experimental models stress: acute stress, chronic their sequences. An was induced in a 60-minute forced swimming test model pool. Chronic simulated by restricting mobility (hypokinesia), which done placing rats into special AE1001-R1 rat retain...

AIM The effect of a depression-like status formed by chronic stress on the development of Lewis lung carcinoma metastases in C57Bl/6J mice was investigated. Two types of acute stress (restraint and social stress) were used for comparison. METHODS The depression-like status was induced by eight-week exposure to repeated but unpredictable stressors (chronic mild stress model) and was assessed i...

Hynynen, Esa Heart rate variability in chronic and acute stress with special reference to nocturnal sleep and acute challenges after awakening Jyväskylä: University of Jyväskylä, 2011, 74 p. (Studies in Sport, Physical Education and Health, ISSN 0356-1070; 163) ISBN 978-951-39-4207-6 (PDF), 978-951-39-4194-9 (nid.) Finnish summary Diss. The present study was designed to investigate the associat...

OBJECTIVE Emergency medical service (EMS) providers are exposed to a variety of stressors endemic to the profession. These exposures may contribute to stress reactions, including posttraumatic stress. The objective of this study was to evaluate the relationship between work-related stressors and posttraumatic stress. The secondary objective was to determine paramedics' preferred sources of supp...