To investigate whether a history of hematolymphoproliferative cancers (HLP) and other cancers among a parent or sibling is a risk factor for specific subtypes of leukemia and non-Hodgkin's lymphoma (NHL), data from a population-based case-control study, in Iowa and Minnesota, of 578 leukemia cases, 622 NHL cases and 1245 controls were evaluated. Having at least one sibling with HLP significantl...

Chronic lymphocytic leukemia (CLL) patients with hepatitis B virus (HBV) infection have a poor prognosis, underlying mechanism remains unclear. NOTCH mutations are frequent in CLL and associated disease progression drug resistance. It is also reported to be lymphoid malignancies. In order investigate the relation between pathway HBV-associated CLL, we studied 98 previously untreated HBV positiv...

Introduction/Objective. Prognostication of chronic lymphocytic leukemia (CLL) has been substantially improved in recent times. Among several prognostic models (PMs) focused on the prediction time to first treatment (TTFT), progression-risk score (PRS), and MD Anderson Cancer Center 2011 (MDACC 2011) are most relevant, while CLL-International Prognostic Index (CLL-IPI), although originally devel...

1. Zenz T, Krober A, Scherer K, et al. Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood. 2008;112(8): 3322-3329. 2. Malcikova J, Smardova J, Rocnova L, et al. Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on sur...

    Chronic lymphocytic leukemia (CLL) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. Many Ferula species, including F. asa-foetida, synthesize terpenyloxy coumarins. One of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines.     In this study induction of apoptosis by umbellipre...

The diagnosis of chronic lymphocytic leukemia (CLL) presenting with ascites is predominantly based on the morphological and immunophenotypic characteristics, which are comparable to peripheral blood and bone marrow cells. However, it is relatively difficult to diagnose CLL due to the pleomorphism of the lymphocytes in ascites. The current study presents an 80-year-old male with a prior diagnosi...

    Chronic lymphocytic leukemia (CLL) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. Many Ferula species, including F. asa-foetida, synthesize terpenyloxy coumarins. One of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines.     In this study induction of apoptosis by umbellipre...

Background: PPreviously, it was shown that exhausted CD4+ and CD8+ T cells in chronic lymphocytic leukemia (CLL) co-express the two immune-inhibitory receptors, Tim-3 and PD-1. Present study investigated the expression of Blimp-1, a transcription factor involved in T cell exhaustion, in patients with CLL. Materials and Methods: Peripheral blood mononuclear cells were collected from 25 untreate...

Background: A subgroup of T and B cells express the extracellular enzyme cluster differentiation (CD73), which hydrolyzes adenosine monophosphate to adenosine. This work aimed evaluate CD73 expression its correlation with other disease characteristics in leukemia chronic lymphocytic type (CLL) patients. Methods: cross-sectional research was done on 30 CLL cases diagnosed by laboratory investiga...

Chronic lymphocytic leukemia (CLL) is known as type of originating from clonal mature B lymphocytes and has genetic heterogeneity. Many studies have been done to clarify the genome CLL. In these studies, del(13q) reported most common chromosomal aberration. Although this anomaly associated with good prognosis when isolated, patients clinical addition, in many gene mutations including TP53, NOTC...