Epidemiological studies indicate that in chronic HD patients, bacterial and viral infection rank second place in mortality and morbidity, behind cardiovascular disease. Chronic hepatitis C virus (HCV) is very prevalent in some Hemodialysis (HD) centers. We have investigated lymphocyte subtype count and immunoglobulin levels in hemodialyzed patient with HCV. We studied 55 patients with end stage...

INTRODUCTION Regulatory T (Treg) and type 1 regulatory T (Tr1) cells facilitate hepatitis C virus (HCV) recurrence after orthotopic liver transplantation (OLT). However, their frequencies and effects on HCV-specific immune responses have not been well investigated. METHODS We determined Treg and Tr1 frequencies in OLT patients with hepatitis C and assessed their associations with HCV-specific...

Background: Chronic hepatitis C virus (HCV) infection induces the occurence of severe chronic liver disease and metabolic complications. Our goal was to study clinical paraclinical profile patients with at Natioanl Teaching Hospital Hubert Koutoukou Maga Cotonou. Methods: This a cross-sectional descriptive conducted Clinic Hepato-Gastroenterology Cotonou treated patients, from January 1, 2012, ...

background and aims: hepatitis c virus is one of the viral infections transmitted by blood transfusion. patients with thalassaemia frequently need blood transfusion and are in danger of hcv infection. in most cases of infection (85%) the virus evades the immune system and establishes a chronic infection that may lead to cirrhosis and liver carcinoma. liver is the main site of hcv replication hc...

INTRODUCTION AND AIM Occult hepatitis C infection (OHCI) is the presence of HCV-RNA in the liver or peripheral blood mononuclear cells (PBMC) accompanying with negative serologic results. The aim of this study was to evaluate the prevalence of OHCI among Iranian chronic hemodialysis (HD) patients. MATERIAL AND METHODS In this cross sectional study 200 chronic HD patients with negative HCV ant...

Chronic infection with hepatitis C virus (HCV) is one of the main causes of hepatocellular carcinoma. However, the molecular mechanisms linking the infection to cancer development remain poorly understood. Here we used HCV-infected cells and liver biopsies to study how HCV modulates the glutaminolysis pathway, which is known to play an important role in cellular energetics, stress defense, and ...

BACKGROUND Infection with hepatitis E virus (HEV) in immunocompromised patients can lead to severe liver disease. Treatment options for HEV include peginterferon or ribavirin, routinely also used for the treatment of hepatitis C virus (HCV) infection. We determined the prevalence and clinical consequences of HEV in United States (US) based patients who underwent liver transplantation (LT) for c...

background: hbv and hcv coinfection is common, particularly in endemic areas and among high risk groups. in this study we have investigated the prevalence of hbv/hcv coinfection and compared the biochemical and serological characteristics of such patients compare with the patients having hepatitis c infection alone.   methods: we studied 207 patients diagnosed as having chronic hepatitis c, wit...

Hepatitis C virus (HCV) is a leading cause of chronic viral hepatitis worldwide. The study of antibody-mediated virus neutralization has been hampered by the lack of an efficient and high-throughput cell culture system for the study of virus neutralization. The HCV structural proteins have been shown to assemble into noninfectious HCV-like particles (HCV-LPs). Similar to serum-derived virions, ...

BACKGROUND Hepatitis C virus (HCV) is known to be a major cause of non-A, non-B hepatitis (NANBH) and is thought to be an important causative agent of serious liver disease. Recently the role of HCV in the development of various liver disease is suggested. METHODS Sera from 222 patients with various liver diseases had been kept frozen at -20 degrees C until the test. Anti-HCV was detected usi...