BACKGROUND Patients with chronic injuries of the proximal hamstring can develop significant impairment because of weakness of the hamstring muscles, sciatic nerve compression from scar formation, or myositis ossificans. PURPOSE To describe the surgical outcomes of patients with chronic injury of the proximal hamstrings who were treated with hamstring repair and sciatic neurolysis supplemented...

Nephrogenic systemic fibrosis is associated with gadolinium contrast exposure in patients with reduced kidney function and carries high morbidity and mortality. We have previously demonstrated that gadolinium contrast agents induce in vivo systemic iron mobilization and in vitro differentiation of peripheral blood mononuclear cells into ferroportin (iron exporter)-expressing fibrocytic cells. I...

There is the need to integrate existing toxicity data in a coherent framework for extending their domain of applicability as well as their extrapolation potential. This integration would also reduce time and cost-consuming aspects of these tests and reduce animal usage. In this work, based on data extracted from literature, we have assessed the advantages that a dynamic biology-toxicant fate co...

Pathogen persistence after clinical cure is a hallmark of many chronic infections. Previously, we showed that naturally occurring CD4+CD25+ regulatory T (nTreg) cells rapidly accumulate within chronic dermal sites of Leishmania major infection where they suppress anti-pathogen CD4+ T cell responses, favor parasite persistence and dermal pathology, and consequently control concomitant immunity. ...

Organophosphate chronic toxicity has been evaluated in this study. Biological screening for organophosphate insecticide-exposed workers is mostly recommended for mixers, loaders, formulators and spraymen. We have studied 17 occupationally exposed persons to pesticides. Using Ellman's colorimetric method, their plasma cholinesterase activities have been measured. Results show that the appear...

Studies carried out on the occupational exposure to paraquat of plantation workers in Malaysia comprised quantitative estimates of dermal and respiratory exposure of knapsack spray operators, carriers, and rubber tappers operating under their normal working conditions. Spray operators have been shown to be dermally exposed to paraquat by walking through recently sprayed vegetation and into thei...

Background: Fish have been at high risk of atrazine toxicity. Comparative atrazine toxicity on the tissues of Clarias gariepinus is scanty. Therefore, acute and chronic effects of atrazine on some biochemical parameters in Clarias gariepinus were investigated in this study. Methods: Atrazine toxicity was determined by assessing the responses of glucose, protein, alanine aminotransferase (ALT...

recently, some natural products have been used in the fields as alternative to synthetic compounds, to minimize the negative impacts to the environment. this study aimed to verify the effects of neem-based bio-pesticide in causing acute toxicity for a fish and chronic toxicity for a microcrustacean. to this end, danio rerio and daphnia magna were exposed to various concentrations of a neem-base...

background: fish have been at high risk of atrazine toxicity. comparative atrazine toxicity on the tissues of clarias gariepinus is scanty. therefore, acute and chronic effects of atrazine on some biochemical parameters in clarias gariepinus were investigated in this study. methods: atrazine toxicity was determined by assessing the responses of glucose, protein, alanine aminotransferase (alt), ...