chromosomal defects are relatively frequent in infertile men however, translocations between the y chromosome and autosomes are rare and less than 40 cases of y-autosome translocation have been reported. in particular, only three individuals has been described with a y;21 translocation, up to now. we report on an additional case of an infertile man in whom a y;21 translocation was associated wi...

Chronic neutrophilic leukemia (CNL) is a rare disease grouped by World Health Organization under the broader category of chronic myeloproliferative diseases. It is a diagnosis of exclusion in patients with sustained mature neutrophilia and splenomegaly with no evidence of other myeloproliferative diseases or reactive neutrophilia. JAK2V617F mutation has been described in classical myeloprolifer...

Background: Lymphocytes of Fanconi anemia (FA) show an increased sensitivity to the alkylating agents such as mitomycin C (MMC), but their responses to gamma-irradiation is controversial. The extent of DNA damage in leukocytes of FA patients following irradiation and MMC treatment was studied at cellular and single chromosome level. Methods: DNA damage induced by gamma-rays and MMC was measure...

Letters to the Editor 151 Fig. 1. Blood film demonstrating chronic myeloid leukemia in lymphoid blast transformation. in beta-thalassemia patients: a single-center experience and a concise review of the literature. Chronic myelogenous leukemia in sickle cell/beta 0-thalassemia. of lymphoma with bone marrow involvement in a boy with beta+ thalassaemia major. Pediatric chronic myeloid leuke-mia w...

Kojima et al recently reported 20 patients with Down’s syndrome and acute leukemia.’ Of these 20 patients, 14 who were 3 years old and less were diagnosed as having acute megakaryoblastic leukemia (AMKL). They were characterized by the presence of bone marrow fibrosis, a history of myelodysplastic syndrome (MDS), and a poor response to chemotherapy. Ten of the 14 patients were male, and platele...

The del(5q) cytogenetic abnormality was first described by Van den Berghe et al. in 1974. 1 The original manuscript described five patients with a macrocytic anemia, dyserythropoiesis with erythroid hypoplasia, normal to elevated platelet count, hypolobulated megakaryocytes and an interstitial deletion involving the long arm of chromosome 5. However, a deletion of chromosome 5q in myelodysplast...

Protein tyrosine phosphatases (PTPases) regulate the tyrosine phosphorylation of target proteins in‌volved in several biological activities including cell proliferation and transformation. Protein tyrosine phosphatase E (PTPE) contains duplicated PTPase-like domains and a short extracellular region. Us‌ing the fluorescence in situ hybridization method, the gene encoding PTPE (locus symbol Ptpre...