نتایج جستجو برای: chromosomal instability

تعداد نتایج: 133476  

2003
Jostein Dahle Egil Kvam

Mutations in critical genes are believed to be a necessary part of cancer induction. The conventional view of radiation mutagenesis is that radiation induces most mutations in cells shortly after irradiation, because of false repair or lack of repair of DNA damage before or during DNA replication. In contrast, we here show that delayed mutations in the hypoxanthine phosphoribosyltransferase loc...

Journal: :Journal of clinical pathology 2003
J E van der Wal M A J A Hermsen H J P Gille N Y N Schouten-Van Meeteren A C Moll S M Imhof G A Meijer J P A Baak P van der Valk

BACKGROUND Retinoblastoma is the most common intraocular malignancy in childhood and is responsible for approximately 1% of all deaths caused by childhood cancer. AIMS/METHODS Comparative genomic hybridisation was performed on 13 consecutive, histologically confirmed retinoblastomas to analyse patterns of chromosomal changes and correlate these to clinicopathological variables. Six cases were...

2012
Katarzyna Piwocka Kamila Wolanin Monika Kusio-Kobialka Paulina Podszywalow-Bartnicka

1.1 Genomic and chromosomal instability in CML An unstable genome is a common hallmark of nearly all solid tumors and most of leukemias in contrast to normal, healthy cells which are able to maintein genome integrity (Negrini et al., 2010). Genomic instability could result from changes in chromosome structure and number as well as changes on the DNA level. Chromosomal instability (CIN) arises f...

2011
Min Wei Federica Madia Valter D. Longo

Studies using the Saccharomyces cerevisiae aging model have uncovered life span regulatory pathways that are partially conserved in higher eukaryotes. The simplicity and power of the yeast aging model can also be explored to study DNA damage and genome maintenance as well as their contributions to diseases during aging. Here, we describe a system to study age-dependent DNA mutations, including ...

Journal: :Cancer research 2003
Luigi Ricciardiello Michele Baglioni Catia Giovannini Milena Pariali Giovanna Cenacchi Alessandro Ripalti Maria Paola Landini Hirofumi Sawa Kazuo Nagashima Richard J Frisque Ajay Goel C Richard Boland Mauro Tognon Enrico Roda Franco Bazzoli

Most colorectal cancers display chromosomal instability, which is characterized by gross chromosomal rearrangements, loss of heterozygosity and aneuploidy. We have previously demonstrated a link between JC virus strains Mad-1 and Delta98 and colorectal cancer. Others have also associated the virus to the induction of colon cancer and aneuploid brain tumors by producing a highly tumorigenic prot...

Hossein Mozdarani, Mohammad Ali Shokrghozar Sahar Moghbeli Nejad Vahideh Farahat

Objective(s) The main objective of this study was to investigate the status of chromosome stability in 3 human-mouse hybridoma cell lines over a period of time in various passages. Materials and Methods Metaphase spreads from 3 human-mouse cell lines (HF2X653, SPMO-4 and F3B6) that had been cultured in 4 successive passages, from 1 to 4 weeks, were prepared and analyzed. Metaphase chromosome...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Yu-Wei Cheng Hanna Pincas Manny D Bacolod Gunter Schemmann Sarah F Giardina Jianmin Huang Sandra Barral Kamran Idrees Sajid A Khan Zhaoshi Zeng Shoshana Rosenberg Daniel A Notterman Jurg Ott Philip Paty Francis Barany

PURPOSE Aberrant promoter methylation and genomic instability occur frequently during colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown to associate with microsatellite instability, and BRAF mutation and is often found in the right-side colon. Nevertheless, the relative importance of CIMP and chromosomal instability (CIN) for tumorigenesis has yet to be thorou...

Journal: :gastroenterology and hepatology from bed to bench 0
ehsan nazemalhosseini mojarad peter jk kuppen hamid asadzadeh aghdaei mohammad reza zali md

it is clear that colorectal cancer (crc) develops through multiple genetic and epigenetic pathways. these pathways may be determined on the basis of three molecular features: (i) mutations in dna mismatch repair genes, leading to a dna microsatellite instability (msi) phenotype, (ii) mutations in apc and other genes that activate wnt pathway, characterized by chromosomal instability (cin) pheno...

Journal: :Essays in biochemistry 2010
Jing Ye Yunlin Wu Eric Gilson

Telomeres are nucleoprotein structures that protect the ends of human chromosomes through the formation of a 'cap', thus preventing exonucleolytic degradation, inter- and intra-chromosomal fusion, and subsequent chromosomal instability. During aging, telomere shortening correlates with tissue dysfunction and loss of renewal capacity. In human cancer, telomere dysfunction is involved in early ch...

Journal: :EMBO reports 2012
Sarah J Pfau Angelika Amon

Aneuploidy is frequently associated with disease and developmental abnormalities. It is also a key characteristic of cancer. Several model systems have been developed to study the role of chromosomal instability and aneuploidy in tumorigenesis. The results are surprisingly complex, with the conditions sometimes promoting and sometimes inhibiting tumour formation. Here, we review the effects of ...

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