New derivatives involving the photochromic 2H-benzo[h]chromene moieties covalently linked to the 2,7-bis(carbazolyl)fluorene-derived two-photon absorbing moiety were designed to enable the possibility of resonance energy transfer from the fluorene donor to the photochromic acceptor. The longest wavelength absorption of the photochromic acceptors overlaps with the fluorescence band of the two-ph...

tention in the search for bioactive compounds to develop new drugs. We have taken note of brown algae of the genus Sargassum (Sargassacea, Fucales), which contain structurally unique secondary metabolites such as palstoquinones, chromanol, and chromenes. In the course of studies on search for bioactive molecules of algae, we isolated plastoquinones [hydroquinone (1) and quinone (2)] together wi...

It is now widely-recognized that the view that herbal remedies have no adverse effects and/or toxicity is incorrect; some traditionally-used plants can present toxicity. The well-established popular use of Ageratum conyzoides has led to its inclusion in a category of medicinal crude drugs created by the Brazilian Health Surveillance Agency. Ageratum belongs to the Eupatorieae tribe, Asteraceae,...

The treatment of β,γ-unsaturated α-ketoesters with phenols in the presence of trityl chloride and 4 Å molecular sieves in refluxing trifluoroacetic acid afforded 4-aryl-2H-chromenes in high yields, in which a reverse of the regiochemistry of Jørgensen-Rutjes chromane synthesis was observed. The isolation of 4H-chromene intermediates, confirmed by single-crystal X-ray analysis, indicates that th...

The apoptosis-inducing activity data of a series of 4-aryl-4H-chromenes based on three cell lines (human breast cancer cell line T47D, human non-smal cell lung cancer cell line H1299, and human colorectal cancer cell line DLD-1) have been subjected to quantitative structure-activity relationship (QSAR) analysis. A collection of chemometrics methods including multiple linear regression (MLR), fa...