Remnants of the notochord sometimes become activated into tumour formation; Ribbert (1895) established the origin of such tumours, and called them chordomata. They can arise at any point along the length of the original notochord, and Coenen (1925) first classified them according to their site of origin into cranial, vertebral, and caudal or sacro-coccygeal. Mabrey (1935) in a comprehensive rev...

OBJECT Chordomas are rare tumors arising from remnants of the notochord. Because of the challenges in achieving a complete resection, the radioresistant nature of these tumors, and the lack of effective chemotherapeutics, the median survival for patients with chordomas is approximately 6 years. Reproducible preclinical model systems that closely mimic the original patient's tumor are essential ...

OBJECTIVE Chordoma is a rare malignant bone tumor with a poor outcome. Although radiotherapy and gamma knife surgery have been used for treatment, providing a cure for the tumor is not easy, because of the frequent recurrences. Molecular targeted therapy against tyrosine kinases has been effective in the treatment of malignancies such as breast and lung cancers and brain tumors. We aimed to ana...

Introduction: Chordoma is a rare type of low-grade malignant neoplasm that arised from the remnants of the embryonic notochord. Observed mainly in the clivus and sacrum but can occur anywhere along the spine. Several treatment approaches are described. Treatment outcomes are significantly influenced by the size and location of the tumor. Clinical presentation and follow up: We report a 19-year-...

STUDY DESIGN This is a retrospective, diagnostic study, level IV. BACKGROUND It appears to be necessary to identify prognostic markers for individual risk estimation for progression and survival in patients with chordoma, a rare disease. Are pre-operative serum levels of C-reactive protein (CRP) associated with disease progression and survival? METHODS Survival rates of 24 patients (18 male...

Background: Chordomas are malignant tumors arising from notochordal remnants and are typically locally aggressive tumors with a high propensity for local recurrence. Method: We report an extremely rare case of cervical spine chordoma presenting with neurological deficit and retropharyngeal extension in order to assess the clinical presentation and treatment. Results: We describe a case of 82-ye...

INTRODUCTION Emerging evidence suggests that microRNAs (miRNAs) are crucially involved in tumorigenesis and that paired expression profiles of miRNAs and mRNAs can be used to identify functional miRNA-target relationships with high precision. However, no studies have applied integrated analysis to miRNA and mRNA profiles in chordomas. The purpose of this study was to provide insights into the p...

OBJECTIVES This study aims to evaluate the clinicopathologic characteristics and treatment modalities of 73 patients with benign and malign sacral tumors and infections from a single institution. PATIENTS AND METHODS Seventy-three patients (42 males, 31 females; mean age 48.9 years), who were treated between July 1991 and December 2013, with benign, malign tumors, and infections of the sacrum...