نتایج جستجو برای: cholinesterase inhibitors
تعداد نتایج: 191405 فیلتر نتایج به سال:
It has been suggested that toxicity to cocaine is related to the relative rate of cocaine metabolism by cholinesterases and to activation of cholinergic receptors either directly or by reflex mechanisms. We examined these possibilities by altering cholinesterase activity and blocking cholinergic receptors in rats prone or resistant to cocaine-induced cardiovascular toxicity. Rats were instrumen...
BACKGROUND Cognitive deficits have been described in patients with schizophrenia from the first descriptions of dementia praecox to current concepts of cognitive dysmetria. Nevertheless, little is known about how to deal with them. In Alzheimer disease, cholinergic deficit is found and cholinesterase inhibitors have been used to delay the progression of memory and cognitive dysfunction. Several...
1. Marked differences in the duration of symptoms were observed when sublethal single doses of different dimethyl phosphate esters were injected intravenously into rats. The compounds inducing prolonged symptoms (OO-dimethyl S-ethylthioethyl phosphorothiolate, OO-dimethyl S-ethylsulphinylethyl phosphorothiolate and OO-dimethyl S-ethylsulphonylethyl phosphorothiolate) either persisted themselves...
BACKGROUND The aim of this study was to use a signal detection method to examine the prevalence of, and patient characteristics associated with, medication with potential to impair cognition and cholinesterase inhibitor use in patients with Alzheimer's disease. METHODS A cross-sectional study was conducted of 1,954 patients with a diagnosis of probable or possible Alzheimer's disease. Concurr...
Sir: Dementia with Lewy bodies (DLB) is characterized clinically by progressive and fluctuating cognitive decline, visual hallucinations, and parkinsonism. Some studies have reported that cholinesterase inhibitors are at least partially beneficial for treating patients with DLB. However, Shea et al. reported that cholinesterase inhibitors occasionally caused deterioration of parkinsonian sympto...
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