The authors describe the case of a female patient with the diagnosis of schizophrenia and the CYP2D6 poor metaboliser phenotype (PM phenotype), who experienced severe extrapyramidal side effects, including acute dystonia, while being treated with chloropromazine at 100 mg per day (in the third day of therapy). The CYP2D6 phenotype was determined using the sparteine test before and after 3 days ...

Chlorpromazine, the prototype phenothiazine tranquilizer, inhibited the growth and killed organisms of the genus Bordetella. There were striking differences, however, among the three Bordetella species. Bordetella pertussis was most susceptible, with some inhibition of growth at greater than or equal to 4 micrograms/ml and killing at 16 micrograms of chlorpromazine per ml. Bordetella parapertus...

In this study, concentrations of cadmium using 3778 samples encompassing the total size Spain (about 505 km2) were investgated. Two novel spatial methods namely Moran eigenvector spatially varying coefficient (MESVC) and filtered unconditional quantile regression (SF-UQR) employed with aim avoiding problem local collinearity which is prevalent in models. Additionally, coefficients applied to as...

Background. Chlorpromazine and trimethoprim-sulfamethoxazole (TMP/SMX) are two commonly prescribed medications by physicians. Either of those medications could cause fatal drug-induced agranulocytosis, with an unclear underlying mechanism. The likelihood of simultaneous prescription of both medications is high and could hypothetically result in severe agranulocytosis that is resistant to treatm...

Objectives. We investigated whether amlodipine could improve angiogenic responses in a diabetic rat model of acute myocardial infarction (AMI) through improving bone marrow endothelial progenitor cell (EPC) mobilization, in the same way as angiotensin converting enzyme inhibitors. Methods. After induction of AMI by coronary artery ligation, diabetic rats were randomly assigned to receive perind...

The effect of chlorpromazine (CPZ) on the shape of human erythrocytes with different values of transmembrane potential (TMP) was investigated. The shape of red blood cells with negative values of the TMP remained unchanged after the formation of stomatocytes by chlorpromazine, while cells with positive TMP showed a characteristic time course of shape change during the incubation with CPZ. Exper...

Both clinical observation and experimental animal studies have shown that chlorpromazine can produce disturbance of normal cardiac rhythm. Atrioventricular and intraventricular conduction defects have been demonstrated, as have various types of tachyarrhythmias, but there have been no reports of complete heart block, associated with the previous presence of right bundle-branch block and left an...