Classic antihistamines, namely diphenhydramine, chlorpheniramine, clemastine, perphenazine, hydroxyzine, and tripelennamine, share structural features with substrates and inhibitors of the polymorphic cytochrome P450 (CYP) isozyme CYP2D6. Therefore, the current study was undertaken to characterize the in vitro inhibition of CYP2D6 by these commonly used, histamine H1 receptor antagonists. Micro...

A 23-year-old female novice, with no previous history of heart disease was prescribed 1. Cap. amoxycillin 250 mg, 1 cap thrice a day 2. A fixed dose combination tablet for cold, 1 tab twice a day, containing: Pseudoephedrine 60 mg Chlorpheniramine 2 mg Bromhexine HCl 8 mg 3. Cough syrup 1 teaspoon thrice a day, each 5 ml containing: Ammonium chloride 100 mg Chlorpheniramine 2 mg Menthol 0.5 mg ...

BACKGROUND Premedication with benzodiazepines has been thought to reduce patient anxiety, pain perception, and non-catheter-induced coronary spasms and may increase procedure-related complications. We used to routinely provide premedication with diazepam and chlorpheniramine before cardiac catheterization procedures. However the benefits of such a treatment are not well established here. Theref...

restraint-induced stress (rs) increases histamine concentration in the brain. there is no previous report regarding the role of histamine receptors in immunomodulatory effect of rs. in the present study the role of brain histamine receptors on reduction of humoral and cellular immune function induced by rs was evaluated. for this purpose male wistar rats (200-250 g) were immunized with sheep re...

Wastewaters are considered one of the main sources pollution in aquatic environment as release a large number contaminants every day. Emerging such pharmaceuticals have special interest due to high levels consumption by global population, their bioactive properties and because actual directives do not include monitoring pharmaceuticals. Moreover, it is well-known that can be degraded metabolite...

Recently, the nasal cavity has been highlighted as an ideal route of administration for interventions it is portal entry severe acute respiratory syndrome coronavirus (SARS-CoV-2). The present study aimed to demonstrate feasibility and efficacy intranasally administered Chlorpheniramine Maleate (CPM) spray treat disease 2019 (COVID-19). Methods: used a two-phase, non-clinical clinical approach....