In the title compound, C(12)H(14)N(2)O, the middle C atom in the propanol chain is a chiral center and possesses an S absolute configuration, according to the synthesis. In the crystal structure, inter-molecular O-H⋯N hydrogen bonds link the mol-ecules into a chain along the b axis.

We derive an index theorem for the Dirac operator in the background of various topological excitations on an R × S geometry. The index theorem provides more refined data than the APS index for an instanton on R and reproduces it in decompactification limit. In the R limit, it reduces to the Callias index theorem. The index is expressed in terms of topological charge and the η-invariant associat...

We derive an index theorem for the Dirac operator in the background of various topological excitations on an R × S geometry. The index theorem provides more refined data than the APS index for an instanton on R and reproduces it in decompactification limit. In the R limit, it reduces to the Callias index theorem. The index is expressed in terms of topological charge and the η-invariant associat...

Compounds a containing bicyclo[1.1.1]pentane (BCP) adjacent to chiral center can be prepared with high enantiomeric excess through asymmetric transfer hydrogenation (ATH) of ketones. In the reduction step, BCP occupies position distant from η6-arene catalyst. The was applied synthesis analogue antihistamine drug neobenodine.

An efficient one-pot three-component procedure for the synthesis of new chiral spiro-oxindolopyrrolizidines with highly regio-, diastereo-, and enantioselective from 1,3-dipolar cycloaddition of azomethine ylides and optically pure active cinamoyl oxazolidinone are described. The process occurs at room temperature in aqueous ethanol as green solvent and in the absence of any bidentate chelating...

trifluoromethylated organic compounds, especially chiral quaternary alcohols bearing trifluoromethyl group are of important intermediates in drugs, agrochemicals and etc.an efficient epoxidation of β-cf3-β,β-disubstituted unsaturated ketones (6) has been developed with environmental benign hydrogen peroxide as the oxidant and f5-substituted chiral quaternary ammonium salt (1g or 5) derived from...

Among the methods for asymmetric synthesis, enantioselective catalysis is one of the representatives to produce enantio-enriched molecules in an efficient and practical manner. Catalytic enantioselective nucleophilic addition to pro-chiral electrophiles such as aldehydes, ketones, imines, and electron deficient double bonds is one of the most extensively investigated reactions, and substantial ...

(-)-Gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized  in the presence  of Candida Antartica lipase.        

one-pot, four-component procedure for the synthesis of a small library of new chiral spiro- oxindolopyrrolidines with high regio-, diastereo- (>99:1 dr), and enantioselectivity (up to 80% ee) is described. in this process, the regio- and stereochemical 1,3-dipolar cycloaddition of azomethine ylides, which were generated insitu by the reaction of isatin derivatives and sarcosin,with optically ac...