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OBJECTIVES Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses the first, irreversible step in lipid A biosynthesis) are a promising new class of antibiotics against Gram-negative bacteria. The objectives of the present study were to: (i) compare the antibiotic activities of three LpxC inhibitors (LPC-058, LPC-011 and LPC-087) and ...
There has been increasing awareness of the importance of three-dimensional culture of cancer cells. Tumor cells growing as multicellular spheroids in three-dimensional culture, alternatively called organoids, are widely believed to more closely mimic solid tumors in situ. Previous studies concluded that the Wnt/β-catenin pathway is required for regeneration of the normal urothelium after injury...
Inducing cardiomyocyte proliferation in post-mitotic adult heart tissue is attracting significant attention as a therapeutic strategy to regenerate the heart after injury. Model animal screens have identified several candidate signalling pathways, however, it remains unclear as to what extent these pathways can be exploited, either individually or in combination, in the human system. The advent...
مطالعه حاضر به منظور ارزیابی وضعیت سلامت کیفیت آب رودخانه شاهرود در استان قزوین انجام شد. نمونه برداری از بزرگ بی مهرگان کفزی با استفاده از نمونه بردار سوربر (مساحت 0/16 مترمربع با چشمه تور 100 میکرون) در تناوب 45 روزه از مهر 1391 تا شهریور 1392 در 9 ایستگاه با 3 تکرار و در طول 95 کیلومتر از این رودخانه انجام شد. نمونه های جمع شده توسط فرمالین 4% تثبیت و به آزمایشگاه منتقل ، جداسازی، شناسایی و...
Cellular microenvironmental conditions coordinate to regulate stem cell populations and their differentiation. Mesenchymal precursor cells (MPCs), which have significant potential for a wide range of therapeutic applications, can be expanded or differentiated into osteo- chondro- and adipogenic lineages. The ability to establish, screen, and control aspects of the microenvironment is paramount ...
Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell-intrinsic mechanism, and identified the GSK-3 inhibitor CHIR99021 as a potent radioprotector. CHIR99021 treatment improved Lgr5+ cell survival a...
A cationic Helicene-NHC hybrid is readily prepared and used for the construction of RhI, AuI AuIII complexes. Ligand controlled chiroptical properties in far-red spectral window are observed.
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