OBJECTIVE Torque teno virus (TTV) infects patients at risk for parenteral exposure and chronic blood transfusion, such as those with β-thalassemic. This study aimed to assess the prevalence of TTV infection and co-infection of TTV and hepatitis C virus (HCV) in pediatric thalassemia patients receiving chronic blood transfusion. MATERIAL AND METHODS The study included 90 pediatric thalassemia ...

AIM This study reports evaluated prevalence of CD in patients with Beta-thalassemia major. BACKGROUND Celiac Disease (CD) is an autoimmune disorder triggered by ingestion of gluten in genetically predisposed individuals. PATIENTS AND METHODS In this case-control study in a period of 3 years, which was performed on 620 children in two groups of Beta-thalassemia major patients (n=200) and con...

OBJECTIVE To devise a strategy for prevention of beta thalassemia in newborns through reliable screening of indexed families. METHODS The cross-sectional study was conducted over six months in 2011 and comprised blood samples collected from subjects belonging to different ethnic groups from families of beta thalassemia major children registered with the Abbottonian Medical Association Blood C...

Most of the techniques for measuring iron stores such as serum iron concentration, iron binding capacity, serum ferritin level, liver biopsy can be troublesome or invasive for patients with thalassemia. The salivary iron measurement could be of potential advantage being an easy and non invasive approach for diagnosis of iron deficiency and iron overload . The aim of this study was to compare th...

BACKGROUND The β-thalassemia syndrome is a genetically inherited commonly encountered hematological disorder in the state of Orissa. It causes high degree of morbidity, mortality and fetal wastage in the poor vulnerable people. AIMS AND OBJECTIVES There is an equal probability (50% chance) in every singleton pregnancy that a carrier parent of β-thalassemia major would either bear normal or ca...

Sickle cell disease (SCD) is an inherited disorder in which sickled red blood cells occlude the small vessels of the body, reducing oxygen delivery to tissues and ultimately negatively affecting many of the body's major organs. Hydroxyurea has proven beneficial in the treatment of SCD and prevention of disease-related complications. The 2014 guidelines put forth by the National Heart, Lung, and...

BACKGROUND Oxidative stress may aggravate symptoms of hemolytic anemias such as beta-thalassemia. FoxO3 activation results in resistance to oxidative stress in fibroblasts and neuronal cell cultures. OBJECTIVE The purpose of this research was to study FoxO3 gene expression and oxidative status in beta-thalassemia minor individuals. METHODS Sixty-three subjects (42 apparently healthy individ...

Background Polypeptide hormone Leptin suppresses inflammation in the heart muscle and protects heart from diseases. The purpose of this study is to evaluate the relationship between leptin and troponin serum levels with cardiac involvement in patients with major beta thalassemia. Materials and Methods In this cross-sectional study, 70 children with major thalassemia were selected. Two ml bl...

Thalassemia major is a hematological single gene disorder that inherited and can cause anemia in affected children, the impact of which world public concern Southeast Asia, including Indonesia. Indonesia one countries thalassemia belt. In Indonesia, more common serious health problem; about 3 – 10% people carry due to abnormal hemoglobin production. More frequent visits hospital have negative o...

Despite frequent blood transfusions combined with chelation therapy lead to an improved rate of survival, endocrine disorders related to secondary hemosiderosis such as short stature, delayed puberty and hypogonadism are major problems in adolescent children with thalassemia major. The aim of this study was to know the description of height, growth velocity, bone age, hemoglobin pretranfusion l...