نتایج جستجو برای: childhood tumor
تعداد نتایج: 574765 فیلتر نتایج به سال:
9510 Background: Survivors of childhood cancer are at increased risk of developing subsequent neoplasms. The incidence and clinical characteristics of subsequent melanoma has not been well described in survivors of childhood cancer. METHODS Analysis included 14,358 5-year survivors of childhood cancer diagnosed between 1970-1986. Cumulative incidence (CIN) of first occurrence of subsequent me...
Glioma is one of the most malignant and fatal tumors in adults. Researchers and physicians endeavor to improve clinical efficacy towards it but made little achievement. In recent years, people have made advances in understanding characteristics and functions of tumor microenvironment and its role in different processes of tumor. In this paper, we describe the effects of tumor microenvironment o...
はじめに 悪性腫瘍は今や日本人の死因の第1位 を占める疾患 であり, 過去4半 世紀の間に多くの進歩は見られたも のの, 現代でもその診断や治療は困難であることが多 い. 近年の分子生物学的な手法による遺伝子解析によ り, 癌の発生, 進展は特定の遺伝子群に起こるDNAの 損傷の蓄積 と考えられている. 化学発癌の考え方では 自然環境中に存在する発癌物質や, 自然界の放射線や, 紫外線によりこれらの遺伝子上のDNAの 損傷(=遺 伝子異常)が 引き起こされると考えられる. 癌化しつ つある細胞はしばしばこれらのDNAの 傷を修復する 機能を失っており, これらの異常が癌遺伝子や癌抑制 遺伝子のような特定の遺伝子群におこるがDNAの 損 傷が固定される結果, ある場合は直接, 細胞の増殖や 脱分化が進行し, (細胞の増殖を自動車にたとえれば自 動車のアクセルをかけることになり)そ の結...
AIM To evaluate the rates of endocrine abnormalities in survivors of childhood brain tumors and identify risk factors. METHODS The medical charts of patients were reviewed for background, disease-related and treatment-related data. Endocrine dysfunction was determined by clinical and laboratory evaluation. RESULTS The study group included 114 patients with a mean age of 15.57 ± 5.93 years. ...
We conducted a hospital-based case-control study in Korea to investigate whether apoptosis- and cell cycle control-related genes are associated with childhood brain tumor. Incident brain tumor cases (N = 70) and non-cancer controls (N = 140), frequency-matched by age and gender, were selected from 3 teaching hospitals in Seoul between 2003 and 2006. Tag single nucleotide polymorphisms (SNPs) (N...
ABSTRACT Neuroblastoma is a tumor with neural cells origin. It usually originated from adrenal gland and sympathetic ganglions. This tumor is the most common tumor in infants and is in forth grade amonge tumors in childhood. In this reaserch we determine to study the prognostic factors in survival of children with neuroblastoma.This is an analytic cross- sectional reaserch on 119 ...
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