It is well-established that hyperthermia increases neuronal death and worsens stroke outcome. However, little is known about the mechanisms of how hyperthermia is involved in this neuronal death process. In the present study, we examined how temperature increase exacerbates neuronal death using a model of chemical ischemia. Chemical ischemia was induced by treating SH-SY5Y neuroblastoma cells w...

Sublethal ischemic challenges can protect neurons against a second, more severe hypoxic insult. We report here that nonlethal chemical ischemia induces a transient alteration of NMDA receptors in rat cortical neurons in culture. Cells were incubated with 3 mM KCN in a glucose-free solution for 90 min. Analysis of NMDA receptor unitary events in patches excised from KCN-treated neurons showed an...

Use of a repetition time similar to, or shorter than, metabolite T(1)s is common in NMR spectroscopy of biological samples to improve the signal-to-noise ratio. Conventionally, the partial saturation that results from this is corrected using saturation factors. However, this can lead to erroneous results in the presence of chemical exchange or nonconstant T(1)s. We describe an alternative appro...

Foreman, R. D., R. W. Blair, H. R. Holmes, and J. A. Armour. Correlation of ventricular mechanosensory neurite activity with myocardial sensory field deformation. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R979–R989, 1999.—The mechanosensory activity generated by ventricular epicardial sensory neurites associated with afferent axons in thoracic sympathetic nerves was correl...

• Blood flow through skeletal muscle is augmented characteristically during and for some time after exercise.-' Information on the basic mechanism of this functional hyperemia is still far from complete. It has been suggested that vasomotor nerves or local chemical imbalances are concerned in the development and maintenance of vasodilatation. Similar uncertainty exists concerning the mechanism ...

Introduction: Cytokines production as one of the inflammatory pathways in CNS is responsible for most brain damages following ischemia. On the other hand, during inflammation and brain ischemia, most of the renin- angiotensin components (RAS) increase locally. While it is established that blockade of RAS especially AT1 receptors has a protective effect on ischemia, the interaction of cytokines ...

ischemia has an important role in spread of pathologic injuries in the neuropathies. it is widely accepted that most damages such as reperfusion injuries, are related to the activity of free radicals. apoptotic signaling was exacerbated by free radicals. the aim of this study was to evaluate the neuroprotective effect of human chorionic gonadotropin (hcg) and vitamin e (trolox) in the hippocamp...

results in all groups ischemic changes were apparently observed in hippocampus ca1 neurons. in two-vessel occlusion model, after 3 and 24 hours of reperfusions, ischemic cells accounted for 14.9% and 23.2%, respectively. in four-vessel occlusion model, after 3 and 24 hours of reperfusions, ischemic cells accounted for 7.6% and 44.9% (p < 0.0001), respectively. background an appropriate animal m...

Chemical exchange saturation transfer (CEST) imaging provides a unique contrast through the exchange between solute protons and bulk water protons 1. It can detect tissue acidosis and elevated protein content in acute ischemia and animal tumor models 2,3. Conventionally, a continuous wave (CW) RF pulse is applied at the solute proton frequency and the saturation is transferred to the bulk water...

The mechanosensory activity generated by ventricular epicardial sensory neurites associated with afferent axons in thoracic sympathetic nerves was correlated with sensory field deformation (long axis, short axis, and transmural dimension changes), regional intramyocardial pressure, and ventricular chamber pressure in anesthetized dogs. Ventricular mechanosensory neurites generated activity that...