نتایج جستجو برای: chemical inhibitors

تعداد نتایج: 557179  

Journal: : 2023

Cancer is one of the most common diseases in world. Th e transcription factor NF-κB plays a key role various physiological processes including immune response, cell proliferation, apoptosis and inflammation. Due to participation NF-kappa B signaling pathways carcinogenesis, angiogenesis, tumor resistance chemo- radiotherapy, considered be ideal target for pharmacological treatment cancer. paper...

Journal: :The Journal of biological chemistry 2010
Hajer Ouertatani-Sakouhi Farah El-Turk Bruno Fauvet Min-Kyu Cho Damla Pinar Karpinar Didier Le Roy Manfred Dewor Thierry Roger Jürgen Bernhagen Thierry Calandra Markus Zweckstetter Hilal A Lashuel

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is considered an attractive therapeutic target in multiple inflammatory and autoimmune disorders. In addition to its known biologic activities, MIF can also function as a tautomerase. Several small molecules have been reported to be effective inhibitors of MIF tautomerase activity in vitro. Herein we employed a robust act...

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