Aldolases derived from various sources may be differentiated into two types according to whether or not they are inhibited by metal-chelating agents (2). Warburg and Christian (3) first recognized a distinctive difference in the properties of yeast and muscle aldolase. The yeast enzyme was strongly inhibited by cyanide, pyrophosphate, cysteine, and cr ,cr’-dipyrridyl, and the inhibition was rev...

Strains of Pseudomonas aeruginosa able to grow readily in serum (serum resistant) produce siderophores in large quantity, enabling them to extract iron from transferrins. The term pyochelin has been proposed for this group of compounds. Pyochelin extractable with ethyl acetate and designated pyochelin A appears to be a mixture of catechols and other phenolates. The structures of water-soluble s...

Ch~lating agents are compounds that fonn metal complexes characterized b)' ring struaurcs ilIusuated in Fig, I.I.~. j In type I th~ metal is coordinated to th~ four nitrogcns of two molecules of ethylcn~ diamine, giving rise to a d1arged cmuble ringed compla ,,'ith cbIorid~ nNtralizing th~ two charges, I Other types of dldating oomplcxes indudc t}"pe II. "ith 81 inm-molccular hydrogen bridge. a...

The effect of several chelating agents (diethyldithiocarbamic acid, DDC; nitrilotriacetic acid, NTA; 2,3-dimercaptopropanol, BAL; d,l-penicillamine, PEN; 2,3-dimercaptosuccinic acid, DMSA; ethylenediaminetetraacetic acid, EDTA; and diethylenetriaminepentaacetic acid, DTPA) on the toxicity, distribution and excretion of cadmium (Cd) was determined in mice. When chelators were administered immedi...

Four chelating agents that have been used most commonly for the treatment of humans intoxicated with lead, mercury, arsenic or other heavy metals and metalloids are reviewed as to their advantages, disadvantages, metabolism and specificity. Of these, CaNa2EDTA and dimercaprol (British anti-lewisite, BAL) are becoming outmoded and can be expected to be replaced by meso-2,3-dimercaptosuccinic aci...

Symptoms and signs in humans after excessive exposure to cadmium usually involve the gastrointestinal tract after single oral intake, the lung after acute inhalation, and the kidney after long-term exposure. These organs are usually considered to be the "critical" organs, i.e., the organs most sensitive at a certain type of exposure. The type of Cd-related damage that is most common in humans i...