نتایج جستجو برای: channel protein

تعداد نتایج: 1431603  

2003
LESLIE J. HOLSINGER H. PINTO

A structure-function analysis of the influenza A virus M2 ion channel protein was performed. The M2 protein of human influenza virus A/Udorn/72 and mutants containing changes on one face of the putative a helix of the M2 transmembrane (TM) domain, several of which lead to amantadine resistance when found in virus, were expressed in oocytes of Xenopus laevis. The membrane currents of oocytes exp...

2011
Michael J. Shipston

Protein S-palmitoylation, the reversible thioester linkage of a 16-carbon palmitate lipid to an intracellular cysteine residue, is rapidly emerging as a fundamental, dynamic, and widespread post-translational mechanism to control the properties and function of ligand- and voltage-gated ion channels. Palmitoylation controls multiple stages in the ion channel life cycle, from maturation to traffi...

2010
Thomas Becker Bernard Guiard Nicolas Thornton Nicole Zufall David A. Stroud Nils Wiedemann Nikolaus Pfanner

The preprotein translocase of the outer mitochondrial membrane (TOM) consists of a central β-barrel channel, Tom40, and six proteins with α-helical transmembrane segments. The precursor of Tom40 is imported from the cytosol by a pre-existing TOM complex and inserted into the outer membrane by the sorting and assembly machinery (SAM). Tom40 then assembles with α-helical Tom proteins to the matur...

The protein family of anion channel (ClC) constitute a family of transmembrane trnsporters that either function as anion channel or as H+/anion exchanger. The expression of three genes of AtClCa, AtClCb and AtClCd in the model plant Arabidopsis thaliana were silenced by a T-DNA insertion . When the pH of the medium was slightly acidic the length of the primary root of plants with a disrupted At...

F. Mollaamin I. Layali T. Nejadsattari

Potassium Channels allow potassium flux and are essential for the generation of electric current acrossexcitable membranes. Potassium Channels are also the targets of various intracellular controlmechanisms; such that the suboptimal regulation of channel function might be related to pathologicalconditions. Realistic studies of ion current in biologic channels present a major challenge for compu...

F. Reshadi Ghader Faraji, M. Baniasadia

Tubular channel angular pressing (TCAP) is a recently invented novel severe plastic deformation technique for producing UFG tubes. Plastic deformation analysis using the finite element method (FEM) was carried out to investigate the effects of trapezoidal channel geometry on strain inhomogeneity index (SII), strain level and required load compared to previously used channel geometries. The resu...

2014
Michael J. Shipston

Protein S-acylation, the reversible covalent fatty-acid modification of cysteine residues, has emerged as a dynamic posttranslational modification (PTM) that controls the diversity, life cycle, and physiological function of numerous ligand- and voltage-gated ion channels. S-acylation is enzymatically mediated by a diverse family of acyltransferases (zDHHCs) and is reversed by acylthioesterases....

2014
Abram Magner Daisuke Kihara Wojciech Szpankowski

In 2008 P. Nurse advocated the pursuit of biological phenomena through information processing. Along these lines, we aim to explain some of the salient characteristics of the mapping between amino acid sequences to protein folds through an information theoretic lens. To this end, we propose a protein folding channel that maps protein sequences into two-dimensional self-avoiding walks (also call...

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