We propose a fast and accurate method for counting the mitotic figures from histopathological slides using regenerative random forest. Our method performs automatic feature selection in an integrated manner with classification. The proposed random forest assigns a weight to each feature (dimension) of the feature vector in a novel manner based on the importance of the feature (dimension). The f...

As recognized by the research community, cyber-physical systems (CPSs) must be reliable, secure, safe, efficient, and operate in real-time. This position paper focuses on (1) the grand challenges for CPSs, (2) requirements for CPSs, and (3) architectures for CPSs. Grand challenges include the design/synthesis, verification, and optimization of CPSs, which require enhancements of existing techni...

Editor’s note: This editorial is part of a series written by editors and co-authored with a senior executive, thought leader, or scholar from a different field to explore new content areas and grand challenges with the goal of expanding the scope, interestingness, and relevance of the work presented in the Academy of Management Journal. The principle is to use the editorial notes as “stage sett...

The American Museum of Natural History in New York City has built a new exhibit space—The Hall of Planet Earth. This hall highlights earth processes using various exhibits including actual rocks and core samples, demonstration models, and video display stations. One specific scientific area that the museum wants to highlight is that of modeling and simulation. Los Alamos has a long history in t...

Due to the exhaustion of IPv4 address resources, the transition from IPv4 to IPv6 is inevitable and fairly urgent. Numerous transition mechanisms have been proposed to solve challenging issues of IPv6 transition. An inter-connection between IPv4 and IPv6 networks or hosts requirement has been happening throughout the IPv6 transition process. And one-time translation scheme is indispensable to a...

The idea of design informatics as a distinguished discipline is a new one, with little precedence. This paper argues for the importance of a humancentered perspective with respect to the emergence of this newly nascent field of design informatics—a perspective which may be termed Human-Centered Design Informatics (HCDI). The paper proposes four grand challenges that are essential to the foundat...

Editor’s note: This editorial is part of a series written by editors and co-authored with a senior executive, thought leader, or scholar from a different field, to explore new content areas and grand challenges with the goal of expanding the scope, interestingness, and relevance of the work presented in the Academy of Management Journal. The principle is to use the editorial notes as “stage set...

Commercial-off-the-shelf (COTS) middleware addresses many design forces for developing mission-critical distributed systems, including reducing development cost and cycle-time. However, meeting additional requirements for real-time quality of service (QoS) in these systems is currently beyond the state-of-the-art in available COTS middleware solutions. In this paper, we discuss key research cha...

Unified collaborative symmetries have led to many natural advances, including semaphores and e-commerce. Here, we verify the understanding of wide-area networks, which embodies the important principles of operating systems. Ash, our new methodology for RAID, is the solution to all of these grand challenges.

Knowing the strategy of an opponent in a competitive environment conveys obvious evolutionary advantages. But this information is costly, and the benefit of being informed may not necessarily offset the additional cost. Here we introduce social dilemmas with informed strategies, and we show that this gives rise to two cyclically dominant triplets that form defensive alliances. The stability of ...