BACKGROUND In older adults hospitalized for heart failure, a poor score on a comprehensive geriatric assessment (CGA) is associated with worse prognosis during hospitalization and at 1 month after discharge. However, the association between the CGA score and long-term mortality is uncertain. METHODS AND RESULTS This is a prospective study of 487 patients aged ≥75 years admitted for decompensa...

Dietary polyphenols are potential contributors toward improved cardiovascular health. Coffee is one of the richest sources of dietary polyphenols in a coffee-drinking population, the most abundant form being chlorogenic acid (CGA). Endothelial dysfunction is an early and major risk factor for cardiovascular disease. Nitric oxide (NO) is a key factor in regulation of endothelial function. Heme o...

Although outpatient Comprehensive Geriatric Assessment (CGA) has shown certain benefits in functional status and quality of life by many randomized controlled trials, no survival benefit has been reported. We hypothesized that the lack of survival benefit may be due to insufficient power of individual trials. In order to assess the influence of outpatient CGA on survival of older persons, we pe...

The antioxidant properties of the dietary dihydroxycinnamic acids [caffeic (CA), dihydrocaffeic (DHCA), and chlorogenic (CGA) acids] have been well studied but little is known about their metabolism. In this article, evidence is presented showing that CA, DHCA, and CGA form quinoids and hydroxylated products when oxidized by peroxidase/H(2)O(2) or tyrosinase/O(2). Mass spectrometry analyses of ...

AIM To explore Trichostatin A (TSA) effect on SGC-7901 gastric cancer cells. METHODS MTT, fluorescence microscopy, and flow cytometry were used to assess TSA effect on cell growth and apoptosis in SGC-7901. Immunocytochemistry was used to evaluate the expression of acetylated histone H4 in SGC-7901 cells.Gene expression profile was determined by microarray assays. Glycoprotein hormones alpha ...

The market for decaffeinated coffees has been increasingly expanding over the years. Caffeine extraction may result in losses of other compounds such as chlorogenic acids (CGA) and, consequently, their 1,5-gamma-quinolactones (CGL) in roasted coffee. These phenolic compounds are important for flavor formation as well as the health effects of coffee; therefore, losses due to decaffeination need ...

The LIM-homeobox transcription factors LHX2 and LHX3s (LHX3a and LHX3b) are thought to be involved in regulating the pituitary glycoprotein hormone subunit genes Cga and Fshβ. These two factors show considerable differences in their amino acid sequences for DNA binding and protein-protein interactions and in their vital function in pituitary development. Hence, we compared the DNA binding prope...

In this paper, we discuss a solution to the problem of improving the design and documentation of computer-generated actor (CGA) systems by exploiting the Unified Modeling Language (UML) to document CGA requirements and uses. The paper contains a brief introduction to the UML and includes a description of its diagrams and documentation capabilities. We describe how the UML has been used to compl...

Optimization by probabilistic modeling is a growing research field in evolutionary computation. An example is the compact genetic algorithm (cGA), in which the population of a genetic algorithm (GA) is represented as a probability distribution over the set of solutions. Both cGA algorithm and the order-one behavior of a simple GA with uniform crossover are operationally equivalent. The cGA is m...

In the most applications in remote sensing, there is no need to use all of available data, such as using all of bands in hyperspectral images. In this paper, a new band selection method was proposed to deal with the large number of hyperspectral images bands. We proposed a Continuous Genetic Algorithm (CGA) to achieve the best subset of hyperspectral images bands, without decreasing Overall Acc...