Rabbits with experimentally induced pneumococcal meningitis were given single 25-mg/kg doses of apalcillin or cefpiramide. Mean percentages of the drug concentration in cerebrospinal fluid versus that in blood serum were 7.6% with apalcillin and 3.9% with cefpiramide. Bactericidal activity in cerebrospinal fluid resulted in mean reductions of from 4 to 5 log10 CFU/ml, and cerebrospinal fluid cu...

26 children with meningococcal infections were studied to find out the relationaship between plasma and cerebrospinal fluid levels of endotoxin, the clinical outcome, the level of antigen in plasma and cerebrospinal fluid, and indices of complement activation and disseminated intravascular coagulation. No association was found between endotoxin levels and the other factors. A high cerebrospinal...

We report a comparison of two cases regarding subjects who underwent thoracoabdominal aorta aneurysmectomy. During the procedure we monitored cerebrospinal fluid lactate concentration. One patient experienced postoperative paraplegia and his cerebrospinal fluid lactate concentration was much higher than that in the other case, whose postoperative outcome was uneventful. Consequently we consider...

Objective To present a case of successful repair of a spontaneous cerebrospinal fluid leak in a previously unreported anatomic site. Methods Retrospective chart review. Results A 48-year-old woman developed a spontaneous cerebrospinal fluid leak from the optic nerve sheath and underwent a multilayer endoscopic closure with no damage to the optic nerve. Conclusion Endoscopic surgeons can s...

We studied the conditions necessary for optimal recovery of bacteria from cerebrospinal fluid. Our results indicated that Streptopcoccus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae can be quantitatively recovered in the sediment after centrifugation at 1,500 X g for 15 min. Equivalent numbers of bacteria were recovered by centrifugation or filtration of antibiotic-free cerebr...

1. Abstract 2. Introduction 3. Structure and Functions of Choroid Plexus 3.1. Structure of choroid plexus 3.2. Functions of choroid plexus 3.3. Composition of cerebrospinal fluid 4. Ageing of Choroid Plexus 4.1. Anatomical modifications in ageing 4.2. Functional alterations in ageing 4.3. Modification of cerebrospinal fluid in ageing 5. Choroid Plexus and Alzheimer’s Disease 5.1. Anatomical alt...

BACKGROUND AND PURPOSE Hepatocyte growth factor (HGF) is a multifunctional cytokine that has been found to be elevated in tuberculous and bacterial meningitis, but no evaluation has been undertaken of its usefulness in identifying various forms of aseptic meningitis. METHODS In a retrospective study, the levels of HGF in the cerebrospinal fluid of 65 patients were measured prior to treatment....

It has been found relatively simple to establish a cerebrospinal fluid bank. Spinal fluid removed at the time of pneumoencephalography may be preserved under sterile conditions by freezing and later used for replacement of cerebrospinal fluid lost at operation. The importance of the composition of solutions used to irrigate the brain or replace lost cerebrospinal fluid has been known for a long...

S1 53rd Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Hugh Richards and Deborah Sival Honorary Publication Secretaries, SRHSB Neurosurgery Unit, Box 167, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700RB Groningen, The Netherlands E-mail: hkr10@m...

Cardiopulmonary resuscitation (CPR) may be followed by slow recovery of brain function. The possible role of bicarbonate therapy was assessed by analysis of arterial blood and cerebrospinal fluid (CSF) in 20 dogs during cardiac arrest and CPR. Samples were taken in the control period and every 5 minutes postarrest for 20 minutes. Group I received no post-arrest CPR. Arterial pH fell from 7.37 t...