Cutaneous hyperpigmentation may be caused by a number of diseases, such as Addison’s disease, scleroderma, haemochromatosis, Peutz-Jeghers syndrome, lichen planus, and adverse reactions to some medications such as oral contraceptives, cyclophosphamide, chloroquine, minocycline, bleomycin, ketoconazole and methyldopa (1). Hyperpigmentation of the tongue, face and body skin is a rare adverse effe...

The author provides his perspective on resurfacing procedures in dark-skinned patients, advising a cautious approach to laser resurfacing. Laser complications in Fitzpatrick skin types III to VI, including hyperpigmentation, hypopigmentation, and scarring, are well documented. Unlike chemical peeling and dermabrasion, with laser resurfacing, preoperative treatment does not control postoperative...

Bleomycin is a chemotherapeutic agent used in the treatment of different tumours. It has several side effects, including flagellate hyperpigmentation, which is a unique and a well-documented side effect of bleomycin therapy. We report a case of a 23-year-old woman with a personal history of ovarian dysgerminoma, who developed flagellate hyperpigmentation on trunk after bleomycin therapy.

Sir, Mucocutaneous side effects associated with bleomycin are stomatitis, ulcers, scaly erythematous and bullous lesions, sclerosis, nail changes, digital gangrene and pigmentary alterations. Hyperpigmentation occurring mainly on the pressure areas of the skin as well as in areas of scratch marks is seen in approximately 30% of patients. Flagellate hyperpigmentation is very characteristic of bl...

Skin hyperpigmentation is characterized as increased production and accumulation of melanin, which could be aesthetically unfavorable and develops serious skin diseases. There is a need to find new depigmenting agents, since many current natural and synthetic products present undesired side effects. In Iranian traditional medicine (ITM), plants have been used for the treatment of skin diseases ...

Minocycline is a tetracycline derivative antibiotic commonly prescribed for acne, rosacea, and other inflammatory skin disorders. Minocycline turns black when oxidized, leading to discoloration of the skin, nails, bulbar conjunctiva, oral mucosa, teeth, bones, and thyroid gland. Hyperpigmentation has been reported after long-term minocycline therapy with at least 100 mg/day. Three types of mino...

INTRODUCTION Familial glucocorticoid deficiency, or hereditary unresponsiveness to adrenocorticotropic hormone, is a rare autosomal recessive disease characterized by glucocorticoid deficiency in the absence of mineralocorticoid deficiency. It may present in infancy or early childhood with hyperpigmentation, failure to thrive, recurrent infections, hypoglycemic attacks and convulsions that may ...

PURPOSE To improve detection and quantification of peripapillary hyperpigmentation, associated with aging, open-angle glaucoma, and age-related macular degeneration. METHODS A computational approach was implemented with a readily available polarimeter used in glaucoma diagnosis, a nerve fiber analyzer (GDx; Laser Diagnostic Technologies, San Diego, CA). Using near-infrared illumination at eac...

Skin hyperpigmentation is characterized as increased production and accumulation of melanin, which could be aesthetically unfavorable and develops serious skin diseases. There is a need to find new depigmenting agents, since many current natural and synthetic products present undesired side effects. In Iranian traditional medicine (ITM), plants have been used for the treatment of skin diseases ...

Hyperpigmentation disorders of the skin are common and can be the source of significant psychosocial distress for patients. The most common of these disorders are melasma and postinflammatory hyperpigmentation. Sunscreen use and minimizing sun exposure are crucial in all cases. Topical applications are the mainstay of treatment and include phenols, retinoids, corticosteroids, and their combinat...