Phytoplankton substitute phosphorus (P) containing lipids with non-P analogues boosting growth in P-limited oceans. In the model diatom Thalassiosira pseudonana, lipid headgroup substitution dynamics are well described, but those of the individual lipids, varying in fatty acids, are unknown. Moreover, the behaviour of lipids outside of the common headgroup classes, and the relationship between ...

The protein kinase C (PKC) family of lipid-activated kinases plays a significant role in the regulation of diverse cellular functions including tumor promotion, apoptosis, differentiation, and others. The lipophilic second messenger diacylglycerols (DAGs) act as endogenous ligands for the PKCs in the presence of anionic phospholipids. To develop effective PKC regulators and understand the impor...

Investigation of the spatial distribution of lipids in cell membranes can lead to an improved understanding of the role of lipids in biological function and disease. Time-of-flight secondary ion mass spectrometry is capable of molecule-specific imaging of biological molecules across single cells and has demonstrated potential for examining the functional segregation of lipids in cell membranes....

Lipids are diverse families of biomolecules that perform essential structural and signaling roles in platelets. Their formation and metabolism are tightly controlled by enzymes and signal transduction pathways, and their dysregulation leads to significant defects in platelet function and disease. Platelet activation is associated with significant changes to membrane lipids, and formation of div...

Background/aim Neuroblastoma is the most common childhood extracranial solid malignancy. Although cancer cells need iron and lipids for active cell division, possible links between lipid metabolism in neuroblastomas have not been studied. Materials methods We evaluated levels association cholesterol on vitro neuroblastoma models. Results found that of are diverse among lines. There a bi-directi...

Aerobic living systems use oxygen (O2) for energy production. However, O2 can become toxic due to the production of reactive species (ROS).
 ROS have complex cell signaling functions, but under an uncontrolled increase in their production, oxidative
 stress (OS) results, which cause damage cellular structures (lipids, proteins, nucleic acids). Faced with oxidative attack, must establi...

We investigate the structure and electronic properties of phosphatidylcholine (PC) under different degrees of hydration at the single-molecule and monolayer type level by linear scaling ab initio calculations. Upon hydration, the phospholipid undergoes drastic long-range conformational rearrangements which lead to a sickle-like ground-state shape. The structural unit of the tilted gel-phase PC ...

Nature constructs intricate complexes containing numerous binding partners in order to direct a variety of cellular processes. Researchers have taken a cue from these events to develop synthetic molecules that can nucleate natural and unnatural interactions for a diverse set of applications. These molecules can be designed to drive protein dimerization or to modulate the interactions between pr...

Five free-living women (ages 23-38 years) who consumed a self-selected diet and five women (ages 23-44 years) residing in a metabolic unit who were fed constant diet were assessed for variation in vitamin and general chemistry indices. Blood was drawn from these women once a month for five months, once a week for five weeks, and once a day for five days to assess analytical and biological varia...

Coccolithophores are a calcifying unicellular phytoplankton group that at the base of marine food web, and their lipid content provides source energy to consumers. vulnerable ocean acidification warming, therefore it is critical establish effects climate change on these significant primary producers, determine potential consequences changes can have Here, we quantified impact in pH temperature ...