نتایج جستجو برای: cellular delivery

تعداد نتایج: 630990  

Journal: :Applied sciences 2021

Drug delivery through the Blood–Brain Barrier (BBB) represents a significant challenge. Despite current strategies to circumvent BBB, nanotechnology offers unprecedented opportunities for combining selective delivery, improved bioavailability, drug protection, and enhanced pharmacokinetics profiles. Chitosan nanocarriers allow more efficacious strategy at cellular sub-cellular levels. Boron Neu...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Sonia S Dharap Pooja Chandna Yang Wang Jayant J Khandare Bo Qiu Stanley Stein Tamara Minko

Chemotherapeutic agents are known to induce programmed cell death or apoptosis. The activation of cellular antiapoptotic defense that prevents the translation of drug-induced damage into cell death is the key factor in cellular antiapoptotic resistance that decreases the chemotherapeutic effectiveness of a broad spectrum of anticancer drugs. A novel proapoptotic anticancer drug delivery system ...

Journal: :Biological & pharmaceutical bulletin 2013
Hiroto Hatakeyama Hidetaka Akita Hideyoshi Harashima

Gene and nucleic acid therapy is expected to play a major role in the next generation of agents for cancer treatment. We have recently developed a multifunctional envelope-type nano device (MEND) for use as a novel nonviral gene delivery system. The modification of polyethyleneglycol (PEG), i.e., PEGylation, is a useful method for achieving a longer circulation time for the delivery of MEND to ...

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