The perihydroxylated perylene quinone hypericin has been reported to possess potent anti-metastatic and antiangiogenic activities, generated by targeting diverse crossroads of cancer-promoting processes via unique mechanisms. Hypericin is the only known exogenous reagent that can induce forced poly-ubiquitination and accelerated degradation of heat shock protein 90 (Hsp90) in cancer cells. Hsp9...

In this study, the Electric Spark Discharge Method (ESDM) was employed with micro-electrical discharge machining (m-EDM) to create an electric arc that melted two electrodes in deionized water (DW) and fabricated nano-Au colloids through pulse discharges with a controlled on-off duration (TON-TOFF) and a total fabrication time of 1 min. A total of six on-off settings were tested under normal ex...

ultraviolet waves, because of their short wavelength, have a high energy and considerable damaging effects on surfaces. protection against ultraviolet radiations is one of the finishing treatments done on surfaces exposed to sunlight. the importance of this issue in relation to human health, due to complications such as skin burns and cancer, is doubled. up to now, different materials such as z...

Abstract Substances with superparamagnetism, a special magnetic effect, are magnetized under external field. When the applied field disappears, superparamagnetic substances have almost zero magnetization intensity, quite small coercivity. The performance of powder or suspension used in particle detection greatly affects sensitivity. This paper studies new method for preparing nano-superparamagn...

good dispersion of nano-particles in polymer matrices is a crucial parameter in determining the final properties of polymer nanocomposites. in this work, the distributions of cloisite 30b, cloisite 10a and cloisite 93a in ptmeg, popular polyols in the polyurethane manufacturing, were investigated in the nano, micro and macro scales. this investigation was carried out using x-ray diffraction, rh...

Background and objectives: Hypericum perforatum L., commonly known as St. John’s wort (SJW) from the family Hypericaceae is a famous medicinal plant used to treat mild to moderate depression; so, it might affect the pharmacokinetics of numerous drugs. Due to widespread herb-drug interactions of SJW, this study was designed to review the clinical evidences regarding the...

AIM The aim of the study was to comparatively analyze the in vitro cell adhesion between nano coated titanium dioxide, and calcium hydroxyapatite (HA) coated titanium samples. MATERIALS AND METHODS Nano coated titanium dioxide, and calcium HA were coated onto the titanium samples by drop casting with NAFION membrane and cell culture was done by seeding human osteoblastic sarcoma cells on the ...

Th is work compares the polyphenolic compounds content in the in vitro shoot cultures of Hypericum rumeliacum, H. tetrapterum and in the hypericin non-producing H. calycinum, which are characteristic for the Balkan fl ora. In addition, the impact of diff erent vitamin supplementation to culture medium on secondary metabolites is discussed. Th ough Gamborg’s vitamins supplementation improved gro...

The wound healing potential of the aerial parts Hypericum triquetrifolium Turra (Hypericaceae) was evaluated using an in vivo excision model rats. Adult male Sprague Dawley rats were randomly assigned into seven groups; blank vehicles (olive oil and petroleum jelly), negative control, treatments [H. ethanolic extract jelly (5% 10%) H. olive macerate (100 200 g/L)], positive control (MEBO). Trea...

In the present study, we evaluated the possibility of enhancing the photodynamic effect of hypericin in transitional cell carcinoma (TCC) spheroids by the use of the oxygen carrier, perfluorodecalin. Following incubation with hypericin, RT-112 TCC spheroids were irradiated in the presence or absence of perfluorodecalin, at light doses of 7 J/cm2 or 28 J/ cm2, delivered at a fluence rate of 15 m...