This month’s report from Saji et al., entitled ‘Basic fibroblast growth factor promotes the trans-differentiation of mouse bone marrow cells into hepatic lineage cells via multiple liver-enriched transcription factors’ [1], is one of a handful of recent papers helping to restore balance to the contentious field of adult stem cell research in general and, more specifically, to investigations of ...

The quadrature method of moments (QMOM) has emerged as a promising tool for the solution of population balance equations in the past few years. The QMOM requires solving differential algebraic equations (DAEs) consisting of ordinary differential equations related to the evolution of moments as well as nonlinear algebraic equations resulting from the quadrature approximation of moments. In this ...

3D Population Balance Model for Continuous Twin Screw Granulator Marko K. Paavola*, Arwa S. El-Hagrasy, James D. Litster, Kauko J. Leiviskä Control Engineering Laboratory, University of Oulu, P. O. Box 4300, FIN 90014, University of Oulu School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA Department of Industrial and Physical Pharmacy, Purdue University, West Lafaye...

Zusammenfassung Der Beitrag beschreibt den Einsatz der Proper Orthogonal Decomposition (POD) für die Modellreduktion von Partikelprozessen in fluider Strömung. Diese Prozessklasse ist von großer Bedeutung für die chemische und pharmazeutische Industrie. Physikalische Modelle solcher Prozesse sind häufig sehr komplex und für Regelungsaufgaben wenig geeignet. POD bietet hier eine attraktive Mögli...

This work extends the granulation model published by Braumann et al. (2007) (Chemical Engineering Science, 62, 4717-4728) to include multiple compartments in order to account for mixture heterogeneity encountered in powder mixing processes. A stochastic weighted algorithm is adapted to solve the granulation model which includes simultaneous coalescence and breakage. Then, a new numerical method...

This work presents a sequential modular approach to solve a generic network of reactors with a population balance model using a stochastic numerical method. Fullcoupling to the gas-phase is achieved through operator-splitting. The convergence of the stochastic particle algorithm in test networks is evaluated as a function of network size, recycle fraction and numerical parameters. These test ca...