White Blood Cell (WBC) cancer or leukemia is one of the serious cancers that threaten existence human beings. In spite its prevalence and consequences, it mostly diagnosed through manual practices. The risks inappropriate, sub-standard wrong biased diagnosis are high in methods. So, there a need exists for automatic classification method can replace process. Leukemia mainly classified into acut...

Abstract Background Richter’s syndrome is the transformation of indolent lymphoma into an aggressive form, most commonly diffuse large B cell lymphoma. Most patients are known to have chronic lymphocytic leukemia. arises in lymph nodes or bone marrow and rarely presents with extra nodal involvement. Case presentation Our patient presented at extremely uncommon site, i.e., testis. This fourth ca...

Monoclonal B-Cell Lymphocytosis (MBL) is part of the mature B-cell neoplasms despite actually being a pre-neoplastic condition [1], this entity, largely unstudied, affects more than 5-10% older adults age 40 and incidence increases with aging [2,3], MBL widely associated as one main risk factors for developing Chronic Lymphocytic Leukemia (CLL)/Small Cell Lymphoma (SLL), since studies Prospecti...

Introduction: Apoptosis is an important mechanism in both physiological and pathological conditions. The BCL2 family of proteins plays a critical role in regulation of apoptotic cell death. Up and down regulation of BCL2-like 12 (BCL2L12), a new member of the BCL2 family, has been reported in several malignancies. However, the expression level of BCL2L12 rarely has been studied in leukemia. T...

background and purpose: leukemia is the most prevalent type of cancer in children and its prognostic factors vary in different geographic locations. the aim of this study was to estimate the 5 years survival rate of children suffering from leukemia in kerman, iran and to investigate the factors which might influence it. materials and methods: this was a cohort study conducted on patients with a...

Acute lymphoblastic leukemia (ALL) is the most common pediatric hematologic malignancy characterized by aberrant proliferation of immature lymphoid cells. A20 a deubiquitinase gene that inhibits functional activation immune cells mediated through nuclear factor κB (NFκB)/signal transducers and activators transcription (STAT) pathways. frequently inactivated in leukemia/lymphoma. Little known ab...

To clarify the nature of null cell acute lymphoblastic leukemia (ALL) we tested null lymphoblasts and other leukemic cells for human T and B lymphocyte antigens detected by reciprocally absorbed rabbit antisera prepared against autologous T and B lymphoblast cell lines HSB-2 and SB. Blasts from 4 of 4 patients with T cell leukemia and from 2 of 10 patients with null cell leukemia expressed T ce...