The development of multicellular organisms relies on the temporal and spatial control of cell proliferation and cell growth. The relationship between cell-cycle progression and development is complex and characterized by mutual dependencies. On the level of the individual cell, this interrelationship has implications for pattern formation and cell morphogenesis. On a supercellular level, this i...

objective: gastric cancer is a major health issue worldwide. using a therapeutic approach, with minor side-effects, is very essential for the treatment of the gastric cancer. shiraia bambusicola is a parasitic fungus which is widely used in china for curing several diseases with little side-effects. however, the mechanisms are not well understood yet. the aim of this study was to further unders...

608 Cells lacking miRNAs (bottom) do not differentiate into muscle (right). miRNAs halt cell cycle M uscle-specifi c miRNAs can induce differentiation at least in part by depleting DNA polymerase α mRNA, according to Kim et al. (page 677). Although other factors are also involved in the differentiation process, obliterating the DNA replication machinery is a novel means to bring the cell cycle ...

Prior to anaphase, sister chromatids must be attached to microtubules and under tension, a condition that satisfies the spindle checkpoint. Removal of sister chromatid cohesion is predicted to cause a fall in tension. Two studies shed light on how cells avoid re-activation of the spindle checkpoint when cohesion is lost.

The 2 major cellular lipid species, sterols and fatty acids, have many roles in physiology. Not only are they essential structural components of eukaryotic cell membranes, but they are also used as sources for cellular energy, serve as precursors for biosynthesis of key cellular macromolecules, are strategically used as post-translational modifications of many proteins, and function as signalin...