نتایج جستجو برای: cell chronic lymphocytic leukemia b
تعداد نتایج: 2734448 فیلتر نتایج به سال:
BACKGROUND The levels and clinical relevance of Th17 cells and other interleukin-17-producing cells have not been analyzed in chronic lymphocytic leukemia. The objective of this study was to quantify blood and tissue levels of Th17 and other interleukin-17-producing cells in patients with this disease and correlate blood levels with clinical outcome. DESIGN AND METHODS Intracellular interleuk...
1. Lischner M, Prokocimer M, Zolberg A, Shaklai M. Autoimmunity in chronic lymphocytic leukaemia. Postgrad Med J 1988;64:590–2. 2. Salvi A, Balestrier GP, Spandrio S, Franceschini R, Maroccolo M, Giustina G. Polymyositis associated with chronic lymphocytic leukemia. Clin Exp Rheumatol 1991;9:209–10. 3. Cherin P, Piette JC, Herson S, Raguin G, Godeau P. Polymyositis associated with chronic lymph...
Chronic lymphocytic leukemia is a lymphoproliferative disorder characterized by a gradual accumulation of neoplastic B-lymphocytes. Ibrutinib is a novel therapy for chronic lymphocytic leukemia. Ibrutinib therapy has been associated with nail plate abnormalities. Other common cutaneous adverse events caused by ibrutinib appear to be bruising, hair changes, pruritus, and rashes. We describe the ...
Summary The treatment landscape of chronic lymphocytic leukemia (CLL) has shifted from chemotherapy-based approaches to targeted agents in the last decade. However, evolving drug resistance and accumulating toxicity remain challenges that still limit patients’ clinical outcomes. Furthermore, currently licensed such as inhibitors Bruton’s tyrosine kinase (BTK) anti-apoptotic protein B‑cell lymph...
We screened serum samples from patients with various hematological disorders and healthy individuals for the presence of adult T-cell leukemia/lymphoma associated antigen (anti-ATLA) antibodies. These antibodies were detected not only in all patients with ATL but frequently in those diagnosed as T-cell malignant lymphoma or T-cell chronic lymphocytic leukemia; the positivity rate of anti-ATLA a...
It is unclear if this is a direct effect or mediated by kinase inhibition. Sphingolipids are also known as mediators of mitochondrial apopto-sis. Consistent with the antiapoptotic effect of glucosylceramide, BCR stimulation reduced the effect of the mitochondria-targeting drug ABT-737. Concomitant treatment with low doses of the kinase (and apparently UGCG) inhibitors GS-1101 and ibrutinib rest...
The presence of an unidentified tumor suppressor gene on the long arm of chromosome 13 which could be involved in the development of B cell chronic lymphocytic leukemia has been suspected because of frequent deletions of the locus D13S25 which lies 1.6 cM telomeric to the retinoblastoma gene. In order to accurately map this gene, cells from 25 B cell chronic lymphocytic leukemia tumors have bee...
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