We conducted an in vivo study with the mouse model of Vibrio vulnificus infection to evaluate the efficacies of therapy with minocycline or cefotaxime alone and in combination. V. vulnificus was introduced subcutaneously into the area over the right thigh. The inoculum size ranged from 1.0 x 10(3) to 1.2 x 10(8) CFU from experiment to experiment but was constant for all animals in the same expe...

Ronald N. Jones, MD, Anti-Infectives Research Center, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242 (USA) I recently read with great concern a publication in your journal entitled, ‘Antibiotic Prophylaxis in the Surgical Treatment of Peritrochanteric Fractures: A Comparative Trial between Two Cephalosporins’ [1]. The cost-effective use of cephalosporins, p...

The stability of the aminoglycosides gentamicin, tobramycin, and amikacin stored in combination with carbenicillin, piperacillin, cefotaxime, and moxalactam was evaluated at four temperatures (25, 4, -8, and -70°C) over a 3-week period. Amikacin was the most stable of the aminoglycosides and demonstrated no loss of activity when stored with either carbenicillin or piperacillin. Gentamicin and t...

A total of 49 Aeromonas isolates obtained from food animals and immunocompromised human cancer patients from Nagpur, were investigated for antibiotic sensitivity pattern by disc diffusion method. Aeromonas spp. exhibited different level of antibiotic sensitivity based on the zone of inhibition observed around the antibiotic disc. Most of the isolates exhibited highest sensitivity towards ceftaz...

While not unique to anti-microbial therapy, Clostridium difficile induced colitis is most frequently encountered as a complication of treatment with one or more of several antibiotics.1 4 The condition has been described in association with some members of the cephalosporin group of drugs.5 Only on a few occasions has cefotaxime been implicated in the past6.11 and, to date, no cases have been r...