There is limited evidence that the tissue-protective effects of erythropoietin are mediated by a heterocomplex of the erythropoietin receptor and the β-common receptor ('tissue-protective receptor'), which is pharmacologically distinct from the 'classical' erythropoietin receptor homodimer that is responsible for erythropoiesis. However, the role of the β-common receptor and/or erythropoietin i...

OBJECTIVES Basal forebrain cholinergic neurons are proposed as a major neuromodulatory system in inflammatory modulation. However, the function of basal forebrain cholinergic neurons in sepsis is unknown, and the neural pathways underlying cholinergic anti-inflammation remain unexplored. DESIGN Animal research. SETTING University research laboratory. SUBJECTS Male wild-type C57BL/6 mice a...

OBJECTIVE Previous in vitro models have shown that cellular deformation causes dose-dependent injury and death in healthy rat alveolar epithelial cells (AECs). We compared the viability of AECs from septic rats with those from nonseptic rats after 1 hr of cyclic equibiaxial stretch. We hypothesized that sepsis would increase stretch-induced cell death. DESIGN Laboratory investigation. SETTI...

Cecal ligation sepsis was studied in eight pentobarbital-anesthetized dogs with hemodynamic measurements at baseline, 2 days after cecal ligation, and following Ringer’s lactate resuscitation. Microsphere techniques were used to measure peripheral arteriovenous (A-V) shunting and distribution of cardiac output. Cecal ligation sepsis was manifested by pyrexia, leukocytosis, decreased blood press...

background: mentha piperita l. essential oils have different antibacterial activity. in the present study, we investigated the effect of γ–irradiation on the antibacterial activities of mentha piperita l. essential oils in vitro and in vivo systems. materials and methods: the aerial parts of peppermint were irradiated in a cobalt60 source with 0, 10 and 25 kgy absorbed doses. then, the plants w...

Objective (s): There is corroborating evidence to substantiate redox imbalance and oxidative stress in sepsis that finally leads to organ damage or even death. Gamma oryzanol (GO) is one of the major bioactive components in rice bran has been considered to function as an antioxidant. The present study was carried out to evaluate the antioxidant activity of gamma oryzanol in vitro and its effica...