let-7 family (various) Downregulated in lung, breast, gastric, ovary, prostate and colon cancers, CLL, leiomyomas; miR-98 downregulated in head and neck cancer. Point mutation in let-7e transcript affects miRNA maturation. Repress cell proliferation and growth. let-7f promotes angiogenesis. Targets: CCND1, CDC25a, CDC34, CDK6, CRDBP, DICER, HMGA2, HOXA9, IMP-1, ITGB3, MYC, RAS, TLR4. SNP in K-R...
