CD8 cells may contribute towards an autoimmune process in COPD. Down regulation of T cell receptor (TCR) signalling molecules occurs in autoimmune diseases with consequent T cell dysfunction. We hypothesise that TCR signalling is abnormal in COPD pulmonary CD8 cells. Micro-array gene expression analysis of blood and pulmonary COPD CD8 samples was performed and compared to pulmonary CD8 cells fr...

CD8 T cells expressing memory markers exist in naive mice and are thought to be of heterogeneous origin. It was recently reported that among such memory-phenotype (MP) CD8 T cells in naive mice, those expressing programmed death-1 (PD-1) had immune regulatory activity, but their origin and relationship with other regulatory CD8 T cell subsets remain unclear. In the current study, we examined de...

CD8+ T cell response is important in the response to viral infections; this response though is regulated by inhibitory receptors. Expression of inhibitory receptors has been positively correlated with CD8+ T cell exhaustion; the consequent effect of simultaneous blockade of these inhibitory receptors on CD8+ T cell response in viral infections have been studied, however, the role of individual ...

CD8 is critical for T cell recognition of peptide/class I major histocompatability complex ligands, yet is down-regulated during activation of CD8 T cells. We report that loss of CD8 expression early during in vivo responses to vaccinia virus or Listeria monocytogenes (LM) correlates with decreased T cell staining with specific class I/peptide tetramers and reduced CD8 T cell sensitivity for an...

CD154, one of the most extensively studied T cell costimulation molecules, represents a promising therapeutic target in organ transplantation. However, the immunological mechanisms of CD154 blockade that result in allograft protection, particularly in the context of alloreactive CD4/CD8 T cell activation, remain to be elucidated. We now report on the profound inhibition of alloreactive CD8(+) T...

the immune responses that develop following epstien-barr virus (ebv) infection are complex and involve both humoral and to a greater extent cell-mediated immune mechanisms. to evaluate the immune response, flow cytometric analysis of the peripheral blood of six patients during the acute phase of ebv infection was performed. this analysis revealed a significant increase in the percentages and th...

considering the emerging importance of phenotypic markers as indicators of cell function and differentiation, we studied patterns ofcd44 and cd45rb expression in cd8+ murine t cells with prior exposure to antigen or staphylococcal enterotoxin b ( seb ). following in vivo priming with two purified protein derivatives (one from a virulent who strain and the other from an avirulent strain), t cell...

in order to study and evaluate the indirect immunofluorescent test and the ratio of cd41ymphocytes to cd8 lymphocytes, 97 cases of positive candida cultures were selected from among 400 patients referring to the hospital and suspected of candidiasis. in this study 39% of the patients had an antibody titer less than 1: 160 no significant correlation was seen between canclidiasis and the results ...

Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection, but impaired immune suppression may be part of the disease pathogenesis. CD8(+) T cells that are restricted by HLA-E exert an important immunoregulatory mechanism. To explore how EBV might interfere with immune regulation, we examined the expression of HLA-E and the frequency of CD8(+) cells recognizing HLA-E, presen...