AIMS To investigate whether MUC1 mucin, a high molecular weight transmembrane glycoprotein, also known as epithelial membrane antigen (EMA), differs in its expression and degree of glycosylation between anaplastic large cell lymphoma (ALCL) and classic Hodgkin's disease (HD), and whether MUC1 immunostaining can be used to differentiate between CD30 positive large cell lymphomas. METHODS/RESUL...

We report the case of a 66-year-old man who consulted with a 3-week history of a rapidly growing asymptomatic lesion on his left cheek that for the previous week had prevented him from opening the eye on that side (Fig. 1). Two years earlier at another center the patient had been diagnosed with a primary systemic CD30 anaplastic large-cell lymphoma (ALCL), with skin lesions in the same area as ...

Mycosis Fungoides (MF) is the most common form of cutaneous T-cell lymphoma, a rare condition which typically presents with erythematous patches and plaques, skin nodules and/or tumors. Advanced disease may progress to more aggressive known as large-cell transformation (LCT). MF be easily confused for psoriasis, deep fungal infection, pyoderma gangrenosum. Psoriasis share features associated ab...

Hodgkin’s lymphoma (HL) is a unique of b-cell origin, the tumor cells which have lost expression main antigens. The standard immunophenotype substrate, according to immunohistochemical studies, characterized by such markers as CD15, CD30 and PAX-5, while negative CD3, CD19 in most cases also CD20 CD45 (or express this antigen rather weakly). knowledge gained recent years has increased effective...

We have recently shown that forced expression of CCR4 by effector T cells enhances their migration to Hodgkin tumor, so that coexpression of both CCR4 and a chimeric antigen receptor directed to the Hodgkin lymphoma (HL)–associated antigen CD30 produces better tumor control when these cells are infused intravenously in mice engrafted with human CD30 /thymus and activationregulated chemokine–sec...

NPM-ALK chimeric transcripts, encoded by the t(2;5), lead to an aberrant expression of ALK by CD30+ systemic lymphomas. To determine if t(2;5) is involved in cutaneous lymphoproliferative disorders, we studied 37 CD30+ cutaneous lymphoproliferations, 27 mycosis fungoides (MF), and 16 benign inflammatory disorders (BID). NPM-ALK transcripts were detected by nested reverse transcription-polymeras...

Several non-Hodgkin lymphoma (NHL) subtypes, including diffuse large B-cell lymphoma (DLBCL), variably express CD30. This phase 2, open-label study evaluated the efficacy of brentuximab vedotin, an anti-CD30 antibody-drug conjugate, in relapsed/refractory CD30(+) NHL. This planned subset analysis of B-cell NHLs includes 49 patients with DLBCL and 19 with other B-cell NHLs. Objective response ra...

CD153 (CD30 ligand) is a member of the TNF ligand/cytokine family expressed on the surface of human B cells. Upon exposure to IL-4, a critical Ig class switch-inducing cytokine, Ag-activated T cells express CD30, the CD153 receptor. The observation that dysregulated IgG, IgA, and/or IgE production is often associated with up-regulation of T cell CD30 prompted us to test the hypothesis that enga...