OBJECTIVE Correlation of CD24 expression with histological grading and TNM staging of retinoblastoma. METHODS This cross-sectional study was conducted in the Department of Pathology, BMSI, JPMC and NICH from 1(st) January 2009 to 31(st) December 2013. A total 68 diagnosed cases of retinoblastoma were selected for CD24 immuno staining. The data was analyzed by using SPSS version 22. RESULTS ...

INTRODUCTION IL-10-producing B cells, Foxp3-expressing T cells (Tregs) and the IDO-expressing dendritic cells (pDC) are able to modulate inflammatory processes, to induce immunological tolerance and, in turn, to inhibit the pathogenesis of autoimmune disease. The aim of the study was to characterize and to enumerate peripheral IL-10--producing B cells, Tregs and pDCregs in primary Sjögren's Syn...

We have investigated the use of a cell surface antigen as a dominant selectable marker to facilitate the detection and selection of retrovirally infected target cells. The small coding region of the human cell surface antigen CD24 (-240 bp) was introduced into a myeloproliferative sarcoma virus (MPSW-based retroviral vector, which was then used to infect day 4 5-fluorouracil (5-FU)-treated muri...

It is well established that T lymphocytes undergo homeostatic proliferation in lymphopenic environment. The homeostatic proliferation requires recognition of the major histocompatibility complex on the host. Recent studies have demonstrated that costimulation-mediated CD28, 4-1BB, and CD40 is not required for T cell homeostatic proliferation. It has been suggested that homeostatic proliferation...

Purpose: To investigate the role of CD24 in tumor invasion and prognostic significance in hepatocellular carcinoma (HCC). Experimental Design: CD24 expression was measured in stepwise metastatic HCC cell lines, tumor, peritumoral tissues, and normal liver tissues by quantitative real-time PCR and Western blot. The role of CD24 in HCC was investigated by CD24 depletion using small interfering RN...

Background Cancer cells are capable of evading clearance by macrophages through the overexpression anti-phagocytic, innate immune checkpoint molecules called ‘don’t eat me’ signals, including CD47, 1 PD-L1, 2 and MHC class I. 3 Monoclonal antibodies that antagonize interaction signals with their macrophage-expressed receptors have demonstrated therapeutic potential in several cancers. However, ...

Introduction: Breast cancer is one of the highest causes death from in women Indonesia. This partly due to resistance ROS-based therapies such as radiotherapy and chemotherapy. stem cells (cancer cells, CSCs) have a role this mechanism. Previous studies demonstrated ability CSC survive oxidative stress conditions rotenone administration. Therefore, study an analysis was carried out on transcrip...

The gene transfer efficiency of human hematopoietic stem cells is still inadequate for efficient gene therapy of most disorders. To overcome this problem, a selectable retroviral vector system for gene therapy has been developed for gene therapy of Gaucher disease. We constructed a bicistronic retroviral vector containing the human glucocerebrosidase (GC) cDNA and the human small cell surface a...

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. Its dismal prognosis is often attributed to the presence of cancer stem cells (CSCs) that have been identified in PDAC using various markers. However, the co-expression of all of these markers has not yet been evaluated. Furthermore, studies that compare the expression levels of CSC markers in PDAC tumor sample...

Although the process of microbial degradation coal to produce biomethane has got much attention from many research works, products profiles at initial stage methanogenic bioconversion are not clear yet. In this study, five coal-degrading bacterial strains (CD1, CD10, CD20, CD24, and CD25) a community were isolated identified. Among them, CD1 CD24 belong Paenibacillus sp., CD10 CD20 Bacillus CD2...