نتایج جستجو برای: cd18 gene

تعداد نتایج: 1142928  

Journal: :Journal of immunology 2001
H Yamagishi T Yokoo T Imasawa T Mitarai T Kawamura Y Utsunomiya

In this study, we used genetically modified bone marrow-derived CD11b(+)CD18(+) vehicle cells to deliver IL-1 receptor antagonist (IL-1ra) for treatment of inflamed renal interstitium in an animal model of unilateral ureteral obstruction (UUO). Vehicle cells that expressed the ICAM-1 ligands, CD11b and CD18, were obtained from bone marrow cells of DBA/2j mice and adenovirally transduced with th...

2014
Tue W Kragstrup Babak Jalilian Malene Hvid Anders Kjærgaard René Østgård Berit Schiøttz-Christensen Anne G Jurik William H Robinson Thomas Vorup-Jensen Bent Deleuran

INTRODUCTION Spondyloarthritis (SpA) comprises a group of diseases often associated with HLA-B27 and characterized by inflammation of the entheses and joints of the axial skeleton. The inflammatory process in SpA is presumably driven by innate immune cells but is still poorly understood. Thus, new tools for monitoring and treating inflammation are needed. The family of CD18 integrins is pivotal...

Journal: :Blood 1994
J D Fortenberry J R Marolda D C Anderson C W Smith M M Mariscalco

Human neonatal neutrophils manifest decreases in mobility, adherence, and emigration compared with adult neutrophils that may contribute to the increased susceptibility of neonates to infection. In a developmental rabbit model, we show a reduced ability of neutrophils from 1-day-old rabbit pups to emigrate to inflamed peritoneium (3.7 +/- 0.35 x 10(6) neutrophils/mL peritoneal exudate) compared...

Journal: :BMC Veterinary Research 2021

Abstract Background Inflammation is believed to influence human colorectal carcinogenesis and may have an impact on prognosis survival. The mucosal immunophenotype in dogs with cancer poorly described. aim of this study was investigate whether the density, distribution grade tumor-infiltrating immune cells (TIIs) are different normal colonic tissue vs benign stages (adenomas) malignant (adenoca...

2017
Abbas Dehnadi A. Benedict Cosimi Rex Neal Smith Xiangen Li José L. Alonso Terry K. Means M. Amin Arnaout

Ischaemic acute kidney injury (AKI), an inflammatory disease process, often progresses to chronic kidney disease (CKD), with no available effective prophylaxis. This is in part due to lack of clinically relevant CKD models in non-human primates. Here we demonstrate that inhibition of the archetypal innate immune receptor CD11b/CD18 prevents progression of AKI to CKD in cynomolgus monkeys. Sever...

Journal: :Journal of biomolecular screening 2007
Jun Y Park M Amin Arnaout Vineet Gupta

The leukocyte-specific integrin CD11b/CD18 plays a key role in the biological function of these cells and represents a validated therapeutic target for inflammatory diseases. Currently, the low affinity interaction between CD11b/CD18 integrin and its respective ligand poses a challenge in the development of cell-based adhesion assays for the high-throughput screening (HTS) environment. Here the...

Journal: :Blood 1995
I Dransfield S C Stocks C Haslett

We have investigated the adhesive capacity of neutrophils after spontaneous apoptosis, which occurs during in vitro culture. Apoptotic neutrophils show reduced adhesion to E selectin and the CD18 integrin ligand fibrinogen. Neutrophil apoptosis is associated with changes in the levels of surface expression of key receptors that mediate neutrophil adhesion events. Notably, apoptotic neutrophils ...

2013
Karin Scharffetter-Kochanek Kamayani Singh Alpaslan Tasdogan Meinhard Wlaschek Martina Gatzka Adelheid Hainzl Thorsten Peters

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