نتایج جستجو برای: cd133 cells

تعداد نتایج: 1384053  

To assess different effects of royal Jelly in protecting the human endothelial cells from high glucose level, human umbilical vein endothelial cells were exposed to various concentrations of royal jelly, from 0.625 to 10 mg/ml, at the presence of 5 and 30 mM glucose contents over a course of 72 h. In addition to cell viability assessment by conventional MTT assay, we also analyzed the feature o...

Journal: :Indian journal of experimental biology 2013
Avvari Bhaskara Balaji Kaiser Jamil Gangaraju Maruthi Ram G Suryanarayana Raju

Skin stem cells are very important in cosmetics, pharmacological and regenerative medicine and burn cases. Foreskin samples surgically removed after circumcision from boys below 7 years were collected and primary epidermal cells were prepared by enzymatic and mechanical tituration method. Selecting CD133 (prominin-1) multipotent stem cell marker, enriched stem cells were analyzed by MACS using ...

Journal: :International journal of cancer 2012
Ilona Kryczek Suling Liu Michael Roh Linhua Vatan Wojciech Szeliga Shuang Wei Mousumi Banerjee Yujun Mao Jan Kotarski Max S Wicha Rebecca Liu Weiping Zou

Identification of cancer stem cells is crucial for advancing cancer biology and therapy. Several markers including CD24, CD44, CD117, CD133, the G subfamily of ATP-binding cassette transporters (ABCG), epithelial specific antigen (ESA) and aldehyde dehydrogenase (ALDH) are used to identify and investigate human epithelial cancer stem cells in the literature. We have now systemically analyzed an...

Journal: :Oncology reports 2012
Yongtao Gao Te Liu Weiwei Cheng Hui Wang

Although the highly proliferative, migratory and multidrug resistant phenotype of human type II endometrial carcinoma (EC) is well characterized, improved clinical treatments have not yet been developed. In this study, CD44 and CD133 were used as markers to screen, isolate and enrich carcinoma-initiating cells (CICs) from the human type II EC cell...

Journal: :Stroke 2010
Francesca Pescini Francesca Cesari Betti Giusti Cristina Sarti Enza Zicari Silvia Bianchi Maria T Dotti Antonio Federico Maurizio Balestrino Adriano Enrico Carlo Gandolfo Anna M Gori Rosanna Abbate Leonardo Pantoni Domenico Inzitari

BACKGROUND AND PURPOSE Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited disease due to cerebral microangiopathy presenting with variable pictures, including stroke, progressive cognitive impairment, and disability. Mechanisms leading from vessel structural changes to parenchymal damage and eventually to clinical expression are ...

2013
Lorena Favaro Pavon Luciana C. Marti Tatiana Tais Sibov Suzana M. F. Malheiros Reynaldo Andre Brandt Sergio Cavalheiro Lionel F. Gamarra

Glioblastomas are the most lethal primary brain tumor that frequently relapse or progress as focal masses after radiation, suggesting that a fraction of tumor cells are responsible for the tumor regrowth. The identification of a brain tumor cell subpopulation with potent tumorigenic activity supports the cancer stem cell hypothesis in solid tumors. The goal of this study is to determine a metho...

Journal: :Molecular medicine 2011
Ilya V Ulasov Suvobroto Nandi Mahua Dey Adam M Sonabend Maciej S Lesniak

Malignant gliomas are currently treated with temozolomide (TMZ), but often exhibit resistance to this agent. CD133(+) cancer stem cells, a population believed to contribute to the tumor's chemoresistance, bear the activation of Notch and Sonic hedgehog (SHH) pathways. In this study, we examined whether inhibition of both pathways enhances the efficacy of TMZ monotherapy in the context of glioma...

Journal: :Cancer research 2012
Chiou-Yan Lai Brian E Schwartz Mei-Yu Hsu

Tumor cell subpopulations that express cancer stem cell markers such as CD133 (prominin1) or ABCB5 are thought to be crucial for tumor initiation and heterogeneity, but their biological significance in melanoma has been controversial. Here, we report that CD133(+) and ABCB5(+) subpopulations are colocalized in melanomas in perivascular niches that contain CD144 (VE-cadherin)(+) melanoma cells f...

2013
Nobumasa Mizuno Yasushi Yatabe Kazuo Hara Susumu Hijioka Hiroshi Imaoka Yasuhiro Shimizu Shigeru B. H. Ko Kenji Yamao

BACKGROUND CD133 has been identified as a cancer stem cell marker for pancreatic ductal adenocarcinoma. Although leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5), a marker of intestinal stem cells, has been shown to be on a higher level of the stem cell hierarchy than CD133, the expression and function of LGR5 in pancreatic cancer tissue remains unclear. This study investigate...

Journal: :International journal of oncology 2012
Yusra Shuho Semba Hiroshi Yokozaki

At the invasive front of colorectal carcinoma (CRC), the existence of tumor budding (TB), the detachment and migration of small clusters of tumor cells from the neoplastic epithelium, correlates with high incidence of local invasion and distant metastasis; however, the molecular background of TB is still unknown. In human CRC-derived SW480 cells, CD133+ cells showed cancer stem cell (CSC)-like ...

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