In the title coordination polymer, [Cd(C(7)H(4)N(3)O(2))(2)(C(3)H(7)NO)(2)](n), the Cd(II) atom, lying on an inversion center, is six-coordinated in a distorted N(4)O(2) octa-hedral geometry. The N atoms of the 4-nitrophenylcyanamide anions form the equatorial plane and the O atoms of the dimethyl-formamide mol-ecules occupy the axial positions. The anions act as bridging ligands, connecting th...

the isolated perfused rat liver (iprl) model has been used into toxicology study of rat liver. this model provides an opportunity at evaluation of liver function in an isolated setting. studies showed that cd, in a dose-dependent manner, induced toxic effects in iprl models, and these effects were associated with aminotransferase activity and lipid peroxidation. the aim of this study was to inv...

In the title compound, [Cd(ClO(4))(2)(C(15)H(18)N(4))(4)], the Cd(II) ion is coordinated in a slightly distorted octa-hedral environment by two trans monodentate perchlorate ligands and four 1-(2-pyrid-yl)-4-(4-pyridylmeth-yl)piperazine (pmpp) ligands. In the crystal structure, mol-ecules are organized into layers parallel to the ab plane by C-H⋯O inter-actions. Similar inter-actions promote th...

BACKGROUND Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus that influences cellular metabolism modifying biological responses. This results in oncogenic, degenerative or inflammatory changes. The myelopathy associated to HTLV-I or tropical spastic paraparesia (HAM/TSP) is a mainly degenerative response to the virus infection. On the other hand, Sjögren syndrome has an inflammato...

The present study investigates the effect of progesterone, a pregnane precursor of neurosteroids, and 4'-chlordiazepam (4'-CD), a specific ligand for mitochondrial diazepam binding inhibitor receptor (MDR) involved in neurosteroidogenesis, on restraint stress (RS)-induced modulation of humoral and cell-mediated immune responses. RS produced a significant reduction in anti-sheep red blood cells ...

BACKGROUND. Morphological patterns of Paneth cells are a prognostic biomarker in Western Crohn's disease (CD) patients, and are associated with autophagy-associated ATG16L1 and NOD2 variants. We hypothesized that genetic determinants of Paneth cell phenotype in other ethnic CD cohorts are distinct but also involved in autophagy. METHODS. We performed a hypothesis-driven analysis of 56 single nu...

This study investigates the effect in rats of acute CdCl(2) (5 microM) intoxication on renal function and characterizes the transport of Ca(2+), Cd(2+), and Zn(2+) in the proximal tubule (PT), loop of Henle (LH), and terminal segments of the nephron (DT) using whole kidney clearance and nephron microinjection techniques. Acute Cd(2+) injection resulted in renal losses of Na(+), K(+), Ca(2+), Mg...

BACKGROUND Celiac disease (CD) is common but underdiagnosed in the United States. A proposed quality guideline recommends that ≥4 specimens be submitted during duodenal biopsy. The degree of adherence to this recommendation in clinical practice is unknown. OBJECTIVE To measure the number of specimens submitted during duodenal biopsy among patients throughout the United States and to determine...

Zinc (Zn) and selenium (Se) exert regulatory activities on immune functions, while cadmium (Cd) is an immunotoxic agent. The object of this study was to detect effects of 10-4, 10-5, and 10-6 M Cd sulphate, Zn sulphate, and sodium selenite, and their combinations on human peripheral blood mononuclear cell (PBMC) proliferation and IFN-γ and TNF-α production. Only 10-5 M Zn sulphate significantly...

Cadmium (Cd) is an environmental hazardous heavy metal that causes renal dysfunction triggered by its toxicity to proximal tubular cells. Our previous study demonstrated Cd changed the activities of various transcription factors (TFs) in mouse kidney. In this study, we investigated whether long-term exposure affected expression levels downstream genes these TFs. C57BL/6J female mice were fed ch...