This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral test...

introduction: glial activation and secretion of cytokines at the spinal level is known as part of chronic pain pathogenesis. although changes in tnfα at the supraspinal level are reported during chronic pain, its exact role and site of action remain to be elucidated. we investigated the effect of microinfusion of tnfα into the lc in a rat model of neuropathic pain. methods: male wistar rats wer...

Channel equalisers are used in digital communication receivers to mitigate the effects of inter symbol interference (ISI) and inter user interference in the form of co-channel interference (CCI) and adjacent channel interference (ACI) in the presence of additive white Gaussian noise (AWGN). An equaliser uses a large part of the computations involved in the receiver. Linear equalisers based on a...

Classification trees (J48) were induced to predict the habitat requirements of tench (Tinca tinca). 306 datasets were used for the given fish during 8 years in the river basins in Flanders (Belgium). The input variables consisted of the structural-habitat (width, depth, gradient slope and distance from the source) and physic chemical (pH, dissolved oxygen, water temperature and electric conduct...

classification trees (j48) were induced to predict the habitat requirements of tench (tinca tinca). 306 datasets were used for the given fish during 8 years in the river basins in flanders (belgium). the input variables consisted of the structural-habitat (width, depth, gradient slope and distance from the source) and physic chemical (ph, dissolved oxygen, water temperature and electric conduct...

BACKGROUND AND OBJECTIVE There is a lack of broadly applicable measures for risk adjustment in pediatric surgical patients necessary for improving outcomes and patient safety. Our objective was to develop a risk stratification model that predicts mortality after surgical operations in children. METHODS The model was created by using inpatient databases from 1988 to 2006. Patients younger than...

background: evidence indicates that neuropathic pain pathogenesis is not confined to changes in the activity of neuronal systems but involves interactions between neurons, inflammatory immune and immune-like glial cells. substances released from immune cells during inflammation play an important role in development and maintenance of neuropathic pain. it has been found that minocycline suppress...

INTRODUCTION. Angiogenesis is one of the critical steps in tumor growth and metastasis. Much attention over the years has been devoted to the notion that tumor blood supply can be targeted with antiangiogenic agents. Our recent study has demonstrated that a mechanism of ezrin-related metastatic behavior is linked to an mTOR pathway, and blockade of this pathway by rapamycin and its analogue CCI...

This paper re-examines the speech rhythm of Beijing Chinese and Pisa Italian by means of the Control/Compensation Index (CCI), with a view to normalizing the speech data, in order to reduce the effect of the rate factor. Two metrics were applied: (a) DnCCI, an adaptation to the CCI model of the nPVI normalization strategy; (b) SnCCI, a z-score normalization, which takes into account the actual ...

PURPOSE The aims of this study were to investigate the effect of hyperbaric oxygen (HBO) treatment at various stages following chronic constriction injury (CCI) and to explore the underlying mechanisms of HBO treatment. METHODS Forty adult male Sprague-Dawley rats were randomly assigned to five groups (n = 8 for each group): the sham group, CCI group, HBO1 group, HBO2 group, and HBO3 group. N...