Hepatitis B virus (HBV) infection is a globally distributed health problem. The number of carriers of HBV is estimated to exceed 240 million people worldwide. Compared with uninfected individuals, HBV carriers have an increased risk of developing hepatocellular carcinoma. The prevention of HBV infection is therefore strongly recommended, and a HBV vaccine is available. For carriers, treatment w...

Cells have developed a number of mechanisms to detect and suppress microbial infections. The use of pattern recognition receptors (PRRs) is one such mechanism. PRRs may be expressed on the cell surface, in the cytosol, or in the endosomes, to detect pathogen-associated molecular patterns (PAMPs) or the danger signals released by damaged cells (i.e., damage-associated molecular patterns; DAMPs)....

Correspondence to: Jung-Hwan Yoon Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea Tel: +82-2-2072-2228, Fax: +82-2-743-6701, E-mail: [email protected] pISSN 1976-2283 eISSN 2005-1212 http://dx.doi.org/10.5009/gnl15307 Current treatments for chronic hepatitis B virus (HBV) infection based o...

Background/Aim. Quantitative hepatitis B surface antigen (qHBsAg) has become increasingly widespread in the last few years both diagnostic and therapeutic protocols for chronic HBV infection. Numerous studies have proposed it as a surrogate marker covalently closed circular DNA (cccDNA). Our study aimed to examine correlation between qHBsAg viremia untreated patients. Methods. The included 112 ...